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1. WO2004076458 - PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES

Publication Number WO/2004/076458
Publication Date 10.09.2004
International Application No. PCT/JP2004/002522
International Filing Date 01.03.2004
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
12
of the kidneys
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
06
Antipsoriatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
04
for myasthenia gravis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A61K 31/519 (2006.01)
A61P 1/00 (2006.01)
A61P 1/16 (2006.01)
A61P 3/10 (2006.01)
A61P 7/00 (2006.01)
A61P 13/12 (2006.01)
CPC
C07D 487/04
Applicants
  • TEIJIN PHARMA LIMITED [JP/JP]; 1-1, Uchisaiwaicho 2-chome Chiyoda-ku Tokyo 1000011, JP (AllExceptUS)
  • KATAOKA, Kenichiro [JP/JP]; JP (UsOnly)
  • SUZUKI, Naotaka [JP/JP]; JP (UsOnly)
  • KOSUGI, Tomomi [JP/JP]; JP (UsOnly)
  • IMAI, Minoru [JP/JP]; JP (UsOnly)
  • MAKINO, Hiroaki [JP/JP]; JP (UsOnly)
  • TAKAKUWA, Mika [JP/JP]; JP (UsOnly)
  • UNOKI, Gen [JP/JP]; JP (UsOnly)
  • FUJINO, Aiko [JP/JP]; JP (UsOnly)
  • OUE, Yasuhiro [JP/JP]; JP (UsOnly)
  • YAMAKOSHI, Yuko [JP/JP]; JP (UsOnly)
  • SUGIURA, Satoshi [JP/JP]; JP (UsOnly)
  • MITCHELL, Dale Robert [GB/GB]; GB (UsOnly)
  • SIMPSON, Donald James [GB/GB]; GB (UsOnly)
  • HARRIS, Clifford John [GB/GB]; GB (UsOnly)
  • LE, Joelle [GB/GB]; GB (UsOnly)
Inventors
  • KATAOKA, Kenichiro; JP
  • SUZUKI, Naotaka; JP
  • KOSUGI, Tomomi; JP
  • IMAI, Minoru; JP
  • MAKINO, Hiroaki; JP
  • TAKAKUWA, Mika; JP
  • UNOKI, Gen; JP
  • FUJINO, Aiko; JP
  • OUE, Yasuhiro; JP
  • YAMAKOSHI, Yuko; JP
  • SUGIURA, Satoshi; JP
  • MITCHELL, Dale Robert; GB
  • SIMPSON, Donald James; GB
  • HARRIS, Clifford John; GB
  • LE, Joelle; GB
Agents
  • MIHARA, Hideko; c/o Teijin Intellectual Property Center Limited 1-1, Uchisaiwaicho 2-chome Chiyoda-ku Tokyo 1000011, JP
Priority Data
0304665.328.02.2003GB
0329446.919.12.2003GB
60/500,69508.09.2003US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES
(FR) DERIVES DE PYRAZOLO[1,5-A]PYRIMIDINE
Abstract
(EN)
The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent kinase inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for a protein kinase mediated disorder in which kinase is implicated, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth. H,N,R3
(FR)
La présente invention a trait à des dérives de pyrazolo[1,5-a]pyrimidine de formule (I) et leurs sels pharmaceutiquement acceptables présentant une excellente activité inhibitrice de la kinase. L'invention a également trait à des médicaments comportant les composés comme principes actifs utiles en tant qu'agents thérapeutiques ou prophylactiques pour un trouble lié à la protéine kinase dans lequel la kinase est impliquée, tel que la maladie inflammatoire, la maladie auto-immune, le trouble destructeur d'os, le cancer et/ou la croissance tumorale.
Also published as
CO05085412
KR1020057015871
NO20053955
NZ542055
PH1-2005-501520
PH12005501520
RU2005130157
US2006189632
ZA200506744
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