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1. (WO2004076458) PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2004/076458 International Application No.: PCT/JP2004/002522
Publication Date: 10.09.2004 International Filing Date: 01.03.2004
IPC:
A61K 31/519 (2006.01) ,A61P 1/00 (2006.01) ,A61P 1/16 (2006.01) ,A61P 3/10 (2006.01) ,A61P 7/00 (2006.01) ,A61P 13/12 (2006.01) ,A61P 17/00 (2006.01) ,A61P 17/06 (2006.01) ,A61P 19/02 (2006.01) ,A61P 19/08 (2006.01) ,A61P 21/04 (2006.01) ,A61P 27/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/02 (2006.01) ,A61P 43/00 (2006.01) ,C07D 487/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
12
of the kidneys
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
06
Antipsoriatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
04
for myasthenia gravis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
KATAOKA, Kenichiro [JP/JP]; JP (UsOnly)
SUZUKI, Naotaka [JP/JP]; JP (UsOnly)
KOSUGI, Tomomi [JP/JP]; JP (UsOnly)
IMAI, Minoru [JP/JP]; JP (UsOnly)
MAKINO, Hiroaki [JP/JP]; JP (UsOnly)
TAKAKUWA, Mika [JP/JP]; JP (UsOnly)
UNOKI, Gen [JP/JP]; JP (UsOnly)
FUJINO, Aiko [JP/JP]; JP (UsOnly)
OUE, Yasuhiro [JP/JP]; JP (UsOnly)
YAMAKOSHI, Yuko [JP/JP]; JP (UsOnly)
SUGIURA, Satoshi [JP/JP]; JP (UsOnly)
MITCHELL, Dale Robert [GB/GB]; GB (UsOnly)
SIMPSON, Donald James [GB/GB]; GB (UsOnly)
HARRIS, Clifford John [GB/GB]; GB (UsOnly)
LE, Joelle [GB/GB]; GB (UsOnly)
TEIJIN PHARMA LIMITED [JP/JP]; 1-1, Uchisaiwaicho 2-chome Chiyoda-ku Tokyo 1000011, JP (AllExceptUS)
Inventors:
KATAOKA, Kenichiro; JP
SUZUKI, Naotaka; JP
KOSUGI, Tomomi; JP
IMAI, Minoru; JP
MAKINO, Hiroaki; JP
TAKAKUWA, Mika; JP
UNOKI, Gen; JP
FUJINO, Aiko; JP
OUE, Yasuhiro; JP
YAMAKOSHI, Yuko; JP
SUGIURA, Satoshi; JP
MITCHELL, Dale Robert; GB
SIMPSON, Donald James; GB
HARRIS, Clifford John; GB
LE, Joelle; GB
Agent:
MIHARA, Hideko; c/o Teijin Intellectual Property Center Limited 1-1, Uchisaiwaicho 2-chome Chiyoda-ku Tokyo 1000011, JP
Priority Data:
0304665.328.02.2003GB
0329446.919.12.2003GB
60/500,69508.09.2003US
Title (EN) PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES
(FR) DERIVES DE PYRAZOLO[1,5-A]PYRIMIDINE
Abstract:
(EN) The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent kinase inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for a protein kinase mediated disorder in which kinase is implicated, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth. H,N,R3
(FR) La présente invention a trait à des dérives de pyrazolo[1,5-a]pyrimidine de formule (I) et leurs sels pharmaceutiquement acceptables présentant une excellente activité inhibitrice de la kinase. L'invention a également trait à des médicaments comportant les composés comme principes actifs utiles en tant qu'agents thérapeutiques ou prophylactiques pour un trouble lié à la protéine kinase dans lequel la kinase est impliquée, tel que la maladie inflammatoire, la maladie auto-immune, le trouble destructeur d'os, le cancer et/ou la croissance tumorale.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)