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1. WO2004067535 - THIENOPYRIMIDINE COMPOUNDS AND USE THEREOF

Publication Number WO/2004/067535
Publication Date 12.08.2004
International Application No. PCT/JP2004/000741
International Filing Date 28.01.2004
Chapter 2 Demand Filed 03.03.2004
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A61K 31/519 (2006.01)
C07D 495/04 (2006.01)
CPC
A61K 31/519
C07D 495/04
Applicants
  • TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410045, JP (AllExceptUS)
  • 長 展生 CHO, Nobuo [JP/JP]; JP (UsOnly)
  • 今田 岐 IMADA, Takashi [JP/JP]; JP (UsOnly)
  • 飛高 武憲 HITAKA, Takenori [JP/JP]; JP (UsOnly)
  • 三輪 憲弘 MIWA, Kazuhiro [JP/JP]; JP (UsOnly)
  • 日下 雅美 KUSAKA, Masami [JP/JP]; JP (UsOnly)
  • 鈴木 伸宏 SUZUKI, Nobuhiro [JP/JP]; JP (UsOnly)
Inventors
  • 長 展生 CHO, Nobuo; JP
  • 今田 岐 IMADA, Takashi; JP
  • 飛高 武憲 HITAKA, Takenori; JP
  • 三輪 憲弘 MIWA, Kazuhiro; JP
  • 日下 雅美 KUSAKA, Masami; JP
  • 鈴木 伸宏 SUZUKI, Nobuhiro; JP
Agents
  • 高橋 秀一 TAKAHASHI, Shuichi; 〒5320024 大阪府大阪市淀川区十三本町2丁目17番85号 武田薬品工業株式会社 大阪工場内 c/o Osaka Plant of TAKEDA PHARMACEUTICAL COMPANY LIMITED 17-85, Jusohonmachi 2-chome, Yodogawa-ku Osaka-shi, Osaka 532-0024, JP
Priority Data
2003-02085429.01.2003JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) THIENOPYRIMIDINE COMPOUNDS AND USE THEREOF
(FR) COMPOSES DE THIENOPYRIMIDINE ET UTILISATION
(JA) チエノピリミジン化合物およびその用途
Abstract
(EN)
It is intended to provide a compound represented by the following general formula or its salt: wherein R1 represents C1-4 alkyl; R2 represents (1) a nitrogen-containing 5- to 7-membered heterocyclic group optionally having a substituent selected from among (1’) halogeno, (2’) hydroxy, (3’) C1-4 alkyl and (4’) C1-4 alkoxy, (2) phenyl optionally having a substituent selected from among (1’) halogeno, (2’) C1-4 alkoxy-C1-4 alkyl, (3’) mono C1-4 alkyl-carbamoyl-C1-4 alkyl, (4’) C1-4 alkoxy and (5’) mono C1-4 alkylcarbamoyl-C1-4 alkoxy, etc.; R3 represents C1-4 alkyl; R4 represents C1-4 alkoxy, etc.; and n is an integer of from 1 to 4; as a thienopyrimidine compound having antagonism to gonadotropin-releasing hormone.
(FR)
L'invention concerne un composé représenté par la formule générale suivante, ou un sel de celui-ci, dans laquelle R1 représente un alkyle C1-4; R2 représente (1) un groupe hétérocyclique de 5 à 7 chaînons contenant de l'azote avec un substituant sélectionné parmi (1') halogéno, (2') hydroxy, (3') un alkyle C1-4 et (4') un alkoxy C1-4, (2) un phényle contenant éventuellement un substituant sélectionné parmi (1') halogéno, (2') un alkyle C1-4 alkoxy C1-4, (3') un mono alkyle C1-4 alkyle-carbamoyle C1-4, (4') un alkoxy C1-4 et (5') un mono alkoxy C1-4 alkyle-carbamoyle C1-4, etc.; R3 représente un alkyle C1-4; R4 représente un alkoxy C1-4, etc.; et n est un entier de 1 à 4. Ce composé est un composé de thiénopyrimidine antagoniste de la gonadolibérine.
(JA)
not available
Also published as
CO05084855
IN01636/KOLNP/2005
IN1636/KOLNP/2005
NO20053974
NZ541772
PH1-2005-501382
PH12005501382
PL378002
PLP.378002
RU2005127052
ZA200506611
Latest bibliographic data on file with the International Bureau