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1. (WO2004048330) N-ARYLSULFONYL-3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2004/048330 International Application No.: PCT/IN2003/000209
Publication Date: 10.06.2004 International Filing Date: 05.06.2003
Chapter 2 Demand Filed: 23.06.2004
IPC:
C07D 209/10 (2006.01) ,C07D 209/12 (2006.01) ,C07D 209/14 (2006.01) ,C07D 209/20 (2006.01) ,C07D 209/42 (2006.01) ,C07D 401/12 (2006.01) ,C07D 403/06 (2006.01) ,C07D 403/12 (2006.01) ,C07D 413/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
10
with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
10
with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
12
Radicals substituted by oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
10
with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
14
Radicals substituted by nitrogen atoms, not forming part of a nitro radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
10
with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
18
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
20
substituted additionally by nitrogen atoms, e.g. tryptophane
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
30
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
42
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
SUVEN LIFE SCIENCES LIMITED [IN/IN]; Serene Chambers Road No. 7 Banjara Hills Hyderabab-500 034 Andra Pradesh, IN (AllExceptUS)
RAMAKRISHNA, Venkata, Satya, Nirogi [IN/IN]; IN (UsOnly)
SHIRSATH, Vikas, Shreekrishna [IN/IN]; IN (UsOnly)
KAMBHAMPATI, Rama, Sastri [IN/IN]; IN (UsOnly)
RAO, Venkata, Satya, Veerabhadra, Vadlamudi [IN/IN]; IN (UsOnly)
JASTI, Venkateswarlu [US/IN]; IN (UsOnly)
Inventors:
RAMAKRISHNA, Venkata, Satya, Nirogi; IN
SHIRSATH, Vikas, Shreekrishna; IN
KAMBHAMPATI, Rama, Sastri; IN
RAO, Venkata, Satya, Veerabhadra, Vadlamudi; IN
JASTI, Venkateswarlu; IN
Agent:
SUBRAMANIAM, Hariharan ; Subramaniam, Nataraj & Associates E- 556, Greater Kailash - II New Delhi 110 048, IN
Priority Data:
884/MAS/200228.11.2002IN
Title (EN) N-ARYLSULFONYL-3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
(FR) INDOLES N-ARYLSULFONYL-3-SUBSTITUES PRESENTANT UNE AFFINITE POUR LE RECEPTEUR DE LA SEROTONINE, METHODE DE PREPARATION ET COMPOSITION PHARMACEUTIQUE CONTENANT CES INDOLES
Abstract:
(EN) The present invention relates to novel N-arylsulfonyl-3-substituted indole compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their geometric forms, their N-oxides, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel N-arylsulfonyl-3-substituted indoles of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, and pharmaceutically acceptable compositions containing them. This invention also relates to the process for preparing compounds of the general formula (I), pharmaceutical compositions containing such compounds and the use of such compounds and compositions in medicine. This invention also relates to the novel intermediates involved therein and process of their preparation.
(FR) La présente invention concerne de nouveaux composés d'indoles N-arylsulfonyl-3-substitués, leurs dérivés, analogues, formes tautomères, stéréoisomères, formes géométriques, N-oxydes, polymorphes, sels pharmaceutiquement acceptables, solvates pharmaceutiquement acceptables, et des compositions pharmaceutiquement acceptables contenant ces composés. L'invention concerne en particulier de nouveaux composés d'indoles N-arylsulfonyl-3-substitués de formule générale (I), leurs dérivés, analogues, formes tautomères, stéréoisomères, polymorphes, sels pharmaceutiquement acceptables, solvates pharmaceutiquement acceptables, et des compositions pharmaceutiquement acceptables contenant ces composés. L'invention concerne en outre la méthode de préparation de composés de formule générale (I), des compositions pharmaceutiques contenant ces composés, et l'utilisation de ces composés et compositions en médecine. L'invention concerne enfin de nouveaux intermédiaires intervenant dans ces composés et compositions et leur méthode de préparation.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20052737NO20085054MXPA/a/2005/005701KR1020050086868ZA2005/04043BRPI0315959
EP1581492JP2006514011US20060223890JP4559230CN1720225CN101544592
CA2509982EA200500881BRPI0318799NZ540840NZ572186AU2003237599
DK1581492BRPI0315959