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1. (WO2004044006) CONJUGATES OF INTERLEUKIN-10 AND POLYMERS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2004/044006 International Application No.: PCT/DK2003/000774
Publication Date: 27.05.2004 International Filing Date: 11.11.2003
IPC:
A61K 38/00 (2006.01) ,A61K 47/48 (2006.01) ,C07K 14/54 (2006.01) ,C07K 17/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
54
Interleukins (IL)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
17
Carrier-bound or immobilised peptides; Preparation thereof
02
Peptides being immobilised on, or in, an organic carrier
08
the carrier being a synthetic polymer
Applicants:
JONES, Jennifer, T. [US/US]; US (UsOnly)
NISSEN, Torben, Lauesgaard [DK/US]; US (UsOnly)
KREBBER, Claus, M. [DE/US]; US (UsOnly)
ANDERSEN, Kim, Vilbour [DK/DK]; DK (UsOnly)
MAXYGEN, INC. [US/US]; 515 Galveston Drive Redwood City, CA 94063, US (AllExceptUS)
Inventors:
JONES, Jennifer, T.; US
NISSEN, Torben, Lauesgaard; US
KREBBER, Claus, M.; US
ANDERSEN, Kim, Vilbour; DK
Agent:
MAXYGEN ApS; Agern Allé 1 DK-2970 Hørsholm, DK
Priority Data:
60/426,68214.11.2002US
Title (EN) CONJUGATES OF INTERLEUKIN-10 AND POLYMERS
(FR) CONJUGUES DE L'INTERLEUKINE-10 ET DE POLYMERES
Abstract:
(EN) Conjugate comprising an interleukin-10 (IL-10) polypeptide and a polymer. The IL-10 has at least one cyteine residue introduced (by substitution) in a position selected form 89 positions. The polymer (e.g. PEG) is attached to cysteine residue of the polypeptide. The conjugate exhibits immunosuppressive activity on T cells, B cells or antigen presenting cells. The conjugate should exhibit a reduced immunostimulatory activity compared to hIL-10. Use of said conjugate for treating inflammatory or autoimmune disease.
(FR) L'invention concerne un conjugué comprenant un polypeptide de l'interleukine-10 (IL-10) et un polymère. L'IL-10 comporte au moins un résidu de cystéine introduit (par substitution) dans une position sélectionnée parmi 89 positions. Le polymère (du PEG, par exemple) est fixé au résidu de cystéine du polypeptide. Ce conjugué présente une activité immuno-suppressive sur les lymphocytes T, les cellules bêta ou les cellules présentatrices de l'antigène. Ce conjugué devrait présenter une activité immuno-stimulante réduite par rapport au hIL-10. L'invention concerne également l'utilisation de ce conjugué pour le traitement de maladies inflammatoires ou auto-immunes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)