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1. (WO2004043985) SUBSTITUTED 9A-N-{N'-[4-(SULFONYL)PHENYL]CARBAMOYL} DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERITHROMYCIN A AND 5-0-DESOSAMINYL­-9-DEOXO-9-DI-HYDRO-9A-AZA-9A-HOMOERITHRONOLIDE A
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2004/043985 International Application No.: PCT/HR2003/000058
Publication Date: 27.05.2004 International Filing Date: 10.11.2003
Chapter 2 Demand Filed: 02.06.2004
IPC:
A61K 31/7048 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7048
having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
Applicants:
KUJUNDZIC, Nedjeljko [HR/HR]; HR (UsOnly)
BUKVIC KRAJACIC, Mirjana [HR/HR]; HR (UsOnly)
BRAJSA, Karmen [HR/HR]; HR (UsOnly)
PLIVA - ISTRAZIVACKI INSTITUT D.O.O. [HR/HR]; Prilaz baruna Filipovica 29 H-10000 Zagreb, HR (AllExceptUS)
Inventors:
KUJUNDZIC, Nedjeljko; HR
BUKVIC KRAJACIC, Mirjana; HR
BRAJSA, Karmen; HR
Agent:
PLIVA - ISTRAZIVACKI INSTITUT D.O.O.; attn. Kresimir Sarcevic Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR
ROS, Zlata; C/o Patentna Pisarna D.O.O. Copova 14 POB 1725 1001 Ljubljana, SI
Priority Data:
P20020885A11.11.2002HR
Title (EN) SUBSTITUTED 9A-N-{N'-[4-(SULFONYL)PHENYL]CARBAMOYL} DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERITHROMYCIN A AND 5-0-DESOSAMINYL­-9-DEOXO-9-DI-HYDRO-9A-AZA-9A-HOMOERITHRONOLIDE A
(FR) DERIVES DE 9-DESOXO-9-DIHYDRO-9A-AZA-9A-HOMOERITHROMYCINE A ET DE 5-0-DESOSAMINYL--9-DESOXO-9-DI-HYDRO-9A-AZA-9A-HOMOERITHRONOLIDE A SUBSTITUES PAR LE GROUPE 9A-N-{N'-[4-(SULFONYL)PHENYL]CARBAMOYL}
Abstract:
(EN) The invention relates to substituted 9a-N-{N'-[4-(sulfonyl)phenyl]carbamoyl} derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin A and 5-0-desosaminyl­-9-deoxo-9-di-hydro-9a-aza-9a-homoerithronolide A, novel semisynthetic macrolide antibiotics of the azalide series general formula (1), wherein R represents H or cladinosyl moiety and R1 represents chloro, amino, phenylamino, 2-pyridylamino, 3,4-dimethyl-4-isoxazolylamino and 5-methyl-3­-isoxazolylamino group, and pharmaceutically acceptable addition salts thereof with inorganic or organic acids, to the process for their preparation of pharmaceutical composition as well as the use their compositions for sterilization rooms and medical instruments as well as for protection of wall and wooden coatings.
(FR) La présente invention concerne des dérivés de 9-désoxo-9-dihydro-9a-aza-9a-homoerithromycine A et de 5-0-desosaminyl--9-deoxo-9-di-hydro-9a-aza-9a-homoerithronolide A substitués par le groupe 9a-N-{N'-[4-(sulfonyl)phényl]carbamoyl}, de nouveaux antibiotiques macrolide semi-synthétiquesde la série azalide représentés par la formule (I) et des sels d'addition répondant aux normes pharmaceutiques de ces composés avec des acides inorganiques ou organiques, le processus de préparation de compositions pharmaceutiques ainsi que l'utilisation de ces compositions pour la stérilisation de pièces et d'instruments chirurgicaux ainsi que pour la protection de paroi et de revêtements de bois. Dans cette formule R représente H ou une fraction cladinosyle et R1 représente un groupe chloro, amino, phénylamino, 2-pyridylamino, 3,4-diméthyl-4-isoxazolylamino et 5-méthyl-3--isoxazolylamino.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)