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1. (WO2004043984) SUBSTITUTED 9a-N-[N'-(BENZENESULFONYL)CARBAMOYL-Y-AMINOPROPYL]AND 9a-N-[N'-(B-CYANEOTHYL)-N'-(BENZENESULFONYL)CARBAMOYL-Y-AMINOPROPYL]DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERITHROMYCIN A AND 5-0-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9A-AZA-HOMOERITHRONOLIDE A
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2004/043984 International Application No.: PCT/HR2003/000057
Publication Date: 27.05.2004 International Filing Date: 10.11.2003
Chapter 2 Demand Filed: 02.06.2004
IPC:
C07H 17/00 (2006.01) ,C07H 17/08 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17
Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17
Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04
Heterocyclic radicals containing only oxygen as ring hetero atoms
08
Hetero rings containing eight or more ring members, e.g. erythromycins
Applicants:
KUJUNDZIC, Nedjeljko [HR/HR]; HR (UsOnly)
BUKVIC KRAJACIC, Mirjana [HR/HR]; HR (UsOnly)
BRAJSA, Karmen [HR/HR]; HR (UsOnly)
PLIVA - ISTRAZIVACKI INSTITUT D.O.O. [HR/HR]; Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR (AllExceptUS)
Inventors:
KUJUNDZIC, Nedjeljko; HR
BUKVIC KRAJACIC, Mirjana; HR
BRAJSA, Karmen; HR
Agent:
REDENSEK, Vladimira; Patenta Pisarna, D.O.O. Copova 14 P.O.B. 1725 1001 Ljubliana, SI
Common
Representative:
PLIVA - ISTRAZIVACKI INSTITUT D.O.O.; attn. Kresimir Sarcevic Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR
Priority Data:
P20020886A11.11.2002HR
Title (EN) SUBSTITUTED 9a-N-[N'-(BENZENESULFONYL)CARBAMOYL-Y-AMINOPROPYL]AND 9a-N-[N'-(B-CYANEOTHYL)-N'-(BENZENESULFONYL)CARBAMOYL-Y-AMINOPROPYL]DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERITHROMYCIN A AND 5-0-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9A-AZA-HOMOERITHRONOLIDE A
(FR) DERIVES DE 9-DESOXO-9-DIHYDRO-9A-AZA-9A-HOMOERITHROMYCINE A ET DE 5-0-DESOSAMINYL-9-DESOXO-9-DIHYDRO-9A-AZA-HOMOERITHRONOLIDE A SUBSTITUES PAR LE GROUPE 9A-N-[N'-(BENZENESULFONYL)CARBAMOYL-Y-AMINOPROPYL] ET PAR LE GROUPE 9A-N-[N'-(B-CYANEOTHYL)-N'-(BENZENESULFONYL)CARBAMOYL-Y-AMINOPROPYLE]
Abstract:
(EN) The invention relates to substituted 9a-N-[N’-(benzenesulfonyl)carbamoyl-ϝ-aminopropyl] and 9a-N-[N’-(&bgr;-cyanoethyl)-N’-(benzenesulfonyl)carbamoyl-ϝ-aminopropyl] derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin A and 5-O-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerithronolide A, novel semisynthetic macrolide antibiotics of the azalide series, of the formula (I) wherein R represents H or cladinosyl moiety, R1 represents H or &bgr;-cyanoethyl group an R2 represents H or fluoro, chloro and methyl group, and pharmaceutically acceptable salts thereof with inorganic or organic acids, to the process for the preparation of pharmaceutical compositions as well as to the use their compositions for sterilization rooms and medical instruments as well as for protection of wall and wooden coatings.
(FR) La présente invention concerne des dérivés de 9-désoxo-9-dihydro-9a-aza-9a-homoérithromycine a et de 5-0-desosaminyl-9-desoxo-9-dihydro-9a-aza-homoerithronolide a substitués par le groupe 9a-n-[n'-(benzènesulfonyl)carbamoyl-y-aminopropyle] et par le groupe 9a-n-[n'-(b-cyanéothyl)-n'-(benzènesulfonyl)carbamoyl-y-aminopropyle], de nouveaux antibiotiques macrolide semi-synthétiques de la série azalide représentés par la formule (I) et des sels de ces composés répondant aux normes pharmaceutiques avec des acides inorganiques ou organiques, le processus de préparation de compositions pharmaceutiques ainsi que l'utilisation de ces compositions pour la stérilisation de pièces et d'instruments chirurgicaux ainsi que pour la protection de paroi et de revêtements de bois. Dans cette formule R représente H ou une fraction cladinosyle et R1 représente H ou un groupe B-cyanoéthyle et R2 représente H ou un groupe fluoro, chloro, et méthyle.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)