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1. (WO2004041186) ANTI-ANGIOGENESIS EFFECTS OF MORINDA CITRIFOLIA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/041186    International Application No.:    PCT/US2003/034652
Publication Date: 21.05.2004 International Filing Date: 31.10.2003
Chapter 2 Demand Filed:    27.05.2004    
IPC:
A61K 35/78
Applicants: MORINDA, INC. [US/US]; 333 W. River Park Drive, Provo, UT 84604 (US)
Inventors: PALU, Afa, Kehaati; (US).
JENSEN, Claude, Jarakae; (US).
LEMUS, David; (CL).
FUENZALIDA, Marcela; (CL).
MIHOVILOVIC, Danilo; (CL)
Agent: KRIEGER, Michael, F.; Kirton & McConkie, 1800 Eagle Gate Tower, 60 East South Temple, Salt Lake City, UT 84111 (US)
Priority Data:
10/286,112 01.11.2002 US
Title (EN) ANTI-ANGIOGENESIS EFFECTS OF MORINDA CITRIFOLIA
(FR) EFFETS ANTI-ANGIOGENESE DE MORINDA CITRIFOLIA
Abstract: front page image
(EN)The present invention features a method of inducing an anti-angiogenesis effect within a tumorous region in the body of a mammal, wherein the method comprises the steps of administering, to a patient, a formulation comprising processed Morinda Citrifolia, wherein the processed Morinda citrifolia blocks formation of new blood vessels within a tumorous region by inhibiting tubule elongation and endothelial cell migration. Blocking the growth factors of said endothelial cells within said tumorous region inhibits tubule elongation and endothelial cell migration. In a preferred embodiment, the processed Morinda citrifolia comprises fruit juice and puree juice in various concentrations.
(FR)La présente invention concerne un procédé de production d'un effet anti-angiogenèse dans une région tumorale du corps d'un mammifère. Ledit procédé procédé consiste à administrer, au patient, une formulation contenant <i>Morinda Citrifolia </i> traité, qui bloque la formation de nouveaux vaisseaux sanguins dans une région tumorale par inhibition de l'élongation des tubules et de la migration des cellules endothéliales. Le blocage des facteurs de croissance desdites cellules endothéliales dans ladite région tumorale inhibe l'élongation des tubules et la migration des cellules endothéliales. Dans un mode de réalisation préféré, le <i>Morinda Citrifolia </i> traité contient du jus de fruit et du jus de purée dans diverses concentrations.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)