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1. WO2004041186 - ANTI-ANGIOGENESIS EFFECTS OF MORINDA CITRIFOLIA

Publication Number WO/2004/041186
Publication Date 21.05.2004
International Application No. PCT/US2003/034652
International Filing Date 31.10.2003
Chapter 2 Demand Filed 27.05.2004
IPC
A61K 35/78
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
78Materials from plants
CPC
A61K 36/746
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
74Rubiaceae (Madder family)
746Morinda
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
Applicants
  • MORINDA, INC. [US]/[US]
Inventors
  • PALU, Afa, Kehaati
  • JENSEN, Claude, Jarakae
  • LEMUS, David
  • FUENZALIDA, Marcela
  • MIHOVILOVIC, Danilo
Agents
  • KRIEGER, Michael, F.
Priority Data
10/286,11201.11.2002US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-ANGIOGENESIS EFFECTS OF MORINDA CITRIFOLIA
(FR) EFFETS ANTI-ANGIOGENESE DE MORINDA CITRIFOLIA
Abstract
(EN)
The present invention features a method of inducing an anti-angiogenesis effect within a tumorous region in the body of a mammal, wherein the method comprises the steps of administering, to a patient, a formulation comprising processed Morinda Citrifolia, wherein the processed Morinda citrifolia blocks formation of new blood vessels within a tumorous region by inhibiting tubule elongation and endothelial cell migration. Blocking the growth factors of said endothelial cells within said tumorous region inhibits tubule elongation and endothelial cell migration. In a preferred embodiment, the processed Morinda citrifolia comprises fruit juice and puree juice in various concentrations.
(FR)
La présente invention concerne un procédé de production d'un effet anti-angiogenèse dans une région tumorale du corps d'un mammifère. Ledit procédé procédé consiste à administrer, au patient, une formulation contenant <i>Morinda Citrifolia </i> traité, qui bloque la formation de nouveaux vaisseaux sanguins dans une région tumorale par inhibition de l'élongation des tubules et de la migration des cellules endothéliales. Le blocage des facteurs de croissance desdites cellules endothéliales dans ladite région tumorale inhibe l'élongation des tubules et la migration des cellules endothéliales. Dans un mode de réalisation préféré, le <i>Morinda Citrifolia </i> traité contient du jus de fruit et du jus de purée dans diverses concentrations.
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