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1. (WO2004036221) COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING AUTOIMMUNE DISEASE

Pub. No.:    WO/2004/036221    International Application No.:    PCT/US2003/033054
Publication Date: Apr 29, 2004 International Filing Date: Oct 17, 2003
IPC: G01N 33/564
Applicants: WYETH
O'TOOLE, Margot, Mary
LIU, Wei
Inventors: O'TOOLE, Margot, Mary
LIU, Wei
Title: COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING AUTOIMMUNE DISEASE
Abstract:
The present invention is generally directed to compositions and methods for the diagnosis, treatment, and prevention of lupus nephritis (LN), to the identification of novel therapeutic agents for LN, and to the creation of cell lines and animal models for studying the pathogenesis of the disease. The present invention is based on the discovery of transcribed polynucleotides that are either over-expressed or under-expressed in animals that develop lupus or are pre-disposed to lupus.