WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2004035623) STABILIZED EXENDIN-4 COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/035623    International Application No.:    PCT/DK2003/000651
Publication Date: 29.04.2004 International Filing Date: 02.10.2003
Chapter 2 Demand Filed:    28.04.2004    
IPC:
A61K 38/22 (2006.01), C07K 14/575 (2006.01)
Applicants: ZEALAND PHARMA A/S [DK/DK]; Smedeland 26B, DK-2600 Glostrup (DK) (For All Designated States Except US).
EBBEHØJ, Kirsten [DK/DK]; (DK) (For US Only).
JEPSEN, Trine [DK/DK]; (DK) (For US Only).
KNUDSEN, Carsten Boye [DK/DK]; (DK) (For US Only).
LARSEN, Bjarne, Due [DK/DK]; (DK) (For US Only).
KNOTT, David [GB/DK]; (DK) (For US Only)
Inventors: EBBEHØJ, Kirsten; (DK).
JEPSEN, Trine; (DK).
KNUDSEN, Carsten Boye; (DK).
LARSEN, Bjarne, Due; (DK).
KNOTT, David; (DK)
Agent: MEWBURN ELLIS LLP; York House, 23 Kingsway, London WC2B 6HP (GB)
Priority Data:
60/415,626 02.10.2002 US
Title (EN) STABILIZED EXENDIN-4 COMPOUNDS
(FR) COMPOSES D'EXENDINE-4 STABILISES
Abstract: front page image
(EN)The present invention disclosed compositions comprising a stabilized Exendin-4 (1-39) and related compounds. The invention describes stabilized Exendin-4 agonists that include at least one modified amino acid residue particularly at positions Gln 13, Met14, Trp25, or Asn28 of the Exendin-4 (1-39) molecule. Disclosed are preferred modifications of deaminated, hydrolyzed, oxidized, or isomerized reaction products of the specified amino acid residues corresponding to the same positions in the Exendin-4 molecule. The invention also relates to methods of making and using the stabilized Exendin compounds, such as for the treatment of diabetes.
(FR)Cette invention se rapporte à des compositions comprenant une exendine-4 (1-39) stabilisée et à des composés apparentés. Cette invention décrit des agonistes d'exendine-4 stabilisées qui contiennent au moins un résidu d'acide aminé modifié particulièrement dans les positions Gln 13, Met14, Trp25, ou Asn28 de la molécule d'exendine-4 (1-39). Cette invention divulgue les modifications préférées de produits de réaction désaminés, hydrolysés, oxydés ou isomérisés de ces résidus d'acide aminé spécifiés correspondant aux mêmes positions dans la molécule d'exendine-4 (1-39). Cette invention concerne également des procédés de production et d'utilisation de ces composés d'exendine stabilisés, par exemple pour le traitement du diabète.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)