WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2004035576) PRE-ORGANIZED TRICYCLIC INTEGRASE INHIBITOR COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/035576    International Application No.:    PCT/US2003/032666
Publication Date: 29.04.2004 International Filing Date: 16.10.2003
Chapter 2 Demand Filed:    13.04.2004    
IPC:
C07D 207/404 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01)
Applicants: GILEAD SCIENCES, INC. [US/US]; 333 Lakeside Drive, Foster City, CA 94404 (US) (For All Designated States Except US).
CHEN, James, M. [US/US]; (US) (For US Only).
CHEN, Xiaowu [US/US]; (US) (For US Only).
FARDIS, Maria [US/US]; (US) (For US Only).
JIN, Haolun [CA/US]; (US) (For US Only).
KIM, Choung, U. [US/US]; (US) (For US Only).
SCHACHERER, Laura, N. [US/US]; (US) (For US Only)
Inventors: CHEN, James, M.; (US).
CHEN, Xiaowu; (US).
FARDIS, Maria; (US).
JIN, Haolun; (US).
KIM, Choung, U.; (US).
SCHACHERER, Laura, N.; (US)
Agent: BOSSE, Mark, L.; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US)
Priority Data:
60/418,963 16.10.2002 US
60/478,783 16.06.2003 US
Title (EN) PRE-ORGANIZED TRICYCLIC INTEGRASE INHIBITOR COMPOUNDS
(FR) COMPOSÉS TRICYCLIQUES PRÉORGANISÉS INHIBITEURS D'INTÉGRASE
Abstract: front page image
(EN)Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. Formula (I). Al and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
(FR)L'invention concerne des composés tricycliques de formule (I), des intermédiaires protégés de ceux-ci, et des méthodes pour inhiber l'intégrase du VIH. Formule (I), où A1 et A2 sont des fractions formant un noyau de cinq, six ou sept éléments, L est une liaison ou un lieur liant un atome cyclique de Ar à N, X signifie O, S ou de l'azote substitué, Ar désigne aryle ou hétéroaryle, Q représente N, +NR ou CR4. Les carbones aryle peuvent être indépendamment substitués par des substituants autres que l'hydrogène. Ces composés peuvent comprendre des fractions de promédicaments liées par covalence à un site quelconque.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)