Search International and National Patent Collections

1. (WO2004035565) METHOD FOR THE SYNTHESIS OF A BENZIMIDAZOLE COMPOUND

Pub. No.:    WO/2004/035565    International Application No.:    PCT/SE2003/001602
Publication Date: Apr 29, 2004 International Filing Date: Oct 15, 2003
IPC: C07D 401/12
Applicants: ASTRAZENECA AB
GUSTAVSSON, Anders
Inventors: GUSTAVSSON, Anders
Title: METHOD FOR THE SYNTHESIS OF A BENZIMIDAZOLE COMPOUND
Abstract:
A process for the manufacture of omeprazole or esomeprazole from pyrmethyl alcohol via pyrmethyl chloride and pyrmetazole characterized in that the whole reaction sequence is carried out without any isolation or purification of intermediates. Further, the reaction is carried out in a solvent system common for the whole reaction sequence and inert to the reactants formed during the process and used in the process and comprises a water immiscible organic solvent and a specified amount of water.