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1. (WO2004035065) HYPOGLYCEMIC SUBSTANCES CONTAINING ZINC
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/035065    International Application No.:    PCT/JP2003/012741
Publication Date: 29.04.2004 International Filing Date: 03.10.2003
IPC:
A61K 31/00 (2006.01), A61K 31/4425 (2006.01), A61K 31/555 (2006.01), A61K 31/60 (2006.01), A61K 31/616 (2006.01), A61K 45/06 (2006.01)
Applicants: ARITA, Junichi [JP/JP]; (JP) (For All Designated States Except US).
KOJIMA, Yoshitane [JP/JP]; (JP) (For US Only).
YOSHIKAWA, Yutaka [JP/JP]; (JP) (For US Only).
KAJIWARA, Naemi [JP/JP]; (JP) (For US Only).
SAKURAI, Hiromu [JP/JP]; (JP) (For US Only).
TANIGUCHI, Hiroshi [JP/JP]; (JP) (For US Only)
Inventors: KOJIMA, Yoshitane; (JP).
YOSHIKAWA, Yutaka; (JP).
KAJIWARA, Naemi; (JP).
SAKURAI, Hiromu; (JP).
TANIGUCHI, Hiroshi; (JP)
Agent: MIKI, Hisami; Haim-Senba 303, 3-8, Kyutaromachi 2-Chome, Chuo-ku, Osaka-city, Osaka 541-0056 (JP)
Priority Data:
2002-304751 18.10.2002 JP
2003-315857 08.09.2003 JP
Title (EN) HYPOGLYCEMIC SUBSTANCES CONTAINING ZINC
(FR) SUBSTANCES HYPOGLYCEMIQUES CONTENANT DU ZINC
(JA) 血糖降下作用を有する亜鉛含有物
Abstract: front page image
(EN)It is intended to develop drugs having hypoglycemic, &agr;-glucosidase inhibitory, antiinflammatory, analgesic, anticancer, antiplatelet and antithrombotic effects as well as an effect of inhibiting blood coagulation causing heart attack and apoplexy by using zinc (II) complexes containing salicylic acid, aspirin, trigonelline and derivatives thereof together with a zinc source. As a result, medicinal preparations and preventives, which have hypoglycemic, &agr;-glucosidase inhibitory, antiinflammatory, analgesic, anticancer, antiplatelet and antithrombotic effects as well as an effect of inhibiting blood coagulation causing heart attack and apoplexy and comprise organic zinc (II) complexes containing, as a ligand, a compound selected from among salicylic acid having a benzene ring, trigonelline having a pyridinium ring and derivatives thereof, are successfully developed.
(FR)L'invention a pour but de développer des médicaments ayant un effet hypoglycémique, inhibiteur d'$g(a)-glucosidase, anti-inflammatoire, analgésique, anticancéreux, antiplaquettaire et antithrombotique, ainsi qu'un effet inhibiteur de la coagulation sanguine, cause d'infarctus du myocarde et d'apoplexie, ceci en utilisant des complexes de zinc (II) contenant de l'acide salicylique, de l'aspirine, de la trigonelline et des dérivés de ces produits, conjointement avec une source de zinc. L'invention concerne en conséquence des préparations médicamenteuses et préventives ayant un effet hypoglycémique, inhibiteur d'$g(a)-glucosidase, anti-inflammatoire, analgésique, anti-cancéreux, antiplaquettaire et antithrombotique, ainsi qu'un effet inhibiteur de la coagulation sanguine, cause d'infarctus du myocarde et d'apoplexie, et comprenant des complexes organiques de zinc (II) contenant, comme ligand, un composé sélectionné à partir d'acide salicylique ayant un noyau benzénique, de trigonelline ayant un noyau pyridinium et de dérivés de ces produits.
(JA) 本発明は、サリチル酸、アスピリン、トリゴネリン、及びそれら誘導体と亜鉛源とを含んでなる亜鉛(ⅠⅠ)錯体を利用して、血糖降下作用、α−グルコシダーゼ阻害作用、抗炎症作用、鎮痛作用、抗がん作用、血小板凝集抑制作用、血栓予防作用、及び心臓の発作や卒中の原因となる血液凝固阻害作用をもつ薬剤を開発することを課題とする。 その結果、本発明は、ベンゼン環を有するサリチル酸、ピリジニウム環を有するトリゴネリンとそれらの誘導体からなる化合物を配位子として含有する亜鉛(ⅠⅠ)有機錯体からなる血糖降下作用、α−グルコシダーゼ阻害作用、抗炎症作用、鎮痛作用、抗がん作用、血小板凝集抑制作用、血栓予防作用、及び心臓の発作や卒中の原因となる血液凝固阻害作用をもつ医薬製剤及び予防剤を完成した。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)