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Machine translation
1. (WO2004034977) ORALLY ADMINISTERED PEPTIDES SYNERGIZE STATIN ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/034977    International Application No.:    PCT/US2003/032442
Publication Date: 29.04.2004 International Filing Date: 14.10.2003
IPC:
A61K 38/00 (2006.01), C07K 14/00 (2006.01), C07K 14/775 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor, Oakland, CA 94607-5200 (US) (For All Designated States Except US).
FOGELMAN, Alan, M. [US/US]; (US) (For US Only).
ANANTHARAMAIAH, Gattadahalli, M. [US/US]; (US) (For US Only).
NAVAB, Mohamad [US/US]; (US) (For US Only)
Inventors: FOGELMAN, Alan, M.; (US).
ANANTHARAMAIAH, Gattadahalli, M.; (US).
NAVAB, Mohamad; (US)
Agent: QUINE, Jonathan, Alan; Quine Intellectual Property Law Group, P.C., P.O. Box 458, Alameda, CA 94501 (US)
Priority Data:
10/273,386 16.10.2002 US
10/423,830 25.04.2003 US
Title (EN) ORALLY ADMINISTERED PEPTIDES SYNERGIZE STATIN ACTIVITY
(FR) PEPTIDES ADMINISTRES PAR VOIE ORALE SYNERGISANT L'ACTIVITE DE LA STATINE
Abstract: front page image
(EN)This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are highly stable and readily administered via an oral route. The peptides are effective to stimulate the formation and cycling of pre-beta high-density lipoprotein-like particles and/or to promote lipid transport and detoxification. This invention also provides a method of tracking a peptide in a mammal. In addition, the peptides inhibit osteoporosis. When administered with a statin, the peptides enhance the activity of the station permitting the station to be used at significantly lower dosages and/or cause the stations to be significantly more anti-inflammatory at any given dose.
(FR)Cette invention concerne de nouveaux peptides améliorant un ou plusieurs symptômes de l'athérosclérose. Ces peptides sont hautement stables et s'administrent facilement par voie orale. Les peptides de l'invention sont efficaces pour stimuler la formation et la circulation de particules pré-béta apparentées à la lipoprotéine de haute densité et/ou promouvoir le transport et/ou la détoxification des lipides. L'invention concerne également un procédé de recherche d'un peptide chez un mammifère. De plus, les peptides de l'invention inhibent l'ostéoporose. Lorsqu'ils sont administrés en association ave une statine, ces peptides améliorent l'activité de la statine et permettent de l'utiliser à des doses considérablement inférieures et/ou en améliorent sensiblement les propriétés anti-inflammatoires à n'importe quelle dose donnée.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)