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1. (WO2004034029) SCREENING SYSTEMS AND METHODS FOR IDENTIFYING MODULATORS OF XENOBIOTIC METABOLISM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/034029    International Application No.:    PCT/US2003/032273
Publication Date: 22.04.2004 International Filing Date: 09.10.2003
Chapter 2 Demand Filed:    29.04.2004    
IPC:
A61K 49/00 (2006.01), C07K 14/72 (2006.01), C12N 15/85 (2006.01)
Applicants: BAYLOR COLLEGE OF MEDICINE [US/US]; One Baylor Plaza, Suite 106A, Houston, TX 77030 (US) (For All Designated States Except US).
MOORE, David, D. [US/US]; (US) (For US Only).
WEI, Ping [CN/US]; (US) (For US Only).
CHUA, Steven, S. [SG/US]; (US) (For US Only)
Inventors: MOORE, David, D.; (US).
WEI, Ping; (US).
CHUA, Steven, S.; (US)
Agent: ACOSTA, Melissa, W.; Fulbright & Jaworski L.L.P., Suite 5100, 1301 McKinney, Houston, TX 77010-3095 (US)
Priority Data:
10/268,822 10.10.2002 US
Title (EN) SCREENING SYSTEMS AND METHODS FOR IDENTIFYING MODULATORS OF XENOBIOTIC METABOLISM
(FR) SYSTEMES ET METHODES DE CRIBLAGE POUR L'IDENTIFICATION DE MODULATEURS DE METABOLISME XENOBIOTIQUE
Abstract: front page image
(EN)The present invention provides mice having reduced CAR receptor activity and mice expressing a human CAR receptor. These mice are useful in screening methods to identify CAR ligands, including compounds that modulate CAR receptor activity, compounds likely to have CAR-mediated toxicity, and analogs of these compounds with less potential toxicity.
(FR)L'invention concerne des souris possédant une activité de récepteur CAR réduite et des souris exprimant un récepteur CAR humain. Ces souris sont utiles dans des méthodes de criblage pour l'identification de ligands de CAR, dont des composés qui modulent l'activité du récepteur CAR, des composés susceptibles de présenter une toxicité médiée par CAR, et des analogues de ces composés présentant une toxicité potentielle moindre.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)