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Machine translation
1. (WO2004033712) ASSAYS FOR C-MANNOSYLTRANSFERASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/033712    International Application No.:    PCT/EP2003/011139
Publication Date: 22.04.2004 International Filing Date: 08.10.2003
Chapter 2 Demand Filed:    23.04.2004    
IPC:
C12Q 1/48 (2006.01)
Applicants: NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG [CH/CH]; Friedrich Miescher Institute For Biomedical Resear, ch, Maulbeerstrasse 66, CH-4058 Basel (CH) (For All Designated States Except US).
HOFSTEENGE, Jan [NL/CH]; (CH) (For US Only).
KEUSCH, Jeremy [GB/CH]; (CH) (For US Only)
Inventors: HOFSTEENGE, Jan; (CH).
KEUSCH, Jeremy; (CH)
Common
Representative:
NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG; Friedrich Miescher Institute For Biomedical Resear, ch, Maulbeerstrasse 66, CH-4058 Basel (CH)
Priority Data:
0223449.0 09.10.2002 GB
Title (EN) ASSAYS FOR C-MANNOSYLTRANSFERASE
(FR) CRIBLAGES RELATIFS A LA C-MANNOSYLTRANSFERASE
Abstract: front page image
(EN)This invention provides cell-based assays for detecting C-Mannosyltransferase (CMT) activity and screening assays for agents effective in modulating CMT activity. The method for assaying C-mannosyltransferase activity comprises the following steps: i) providing a cell comprising CMT and a fusion protein, said fusion protein comprising a CMT substrate and a transmembrane domain, ii) providing conditions conductive to forming a C-mannosylated CMT substrate by action of said CMT substrate in said cell; and iii) detecting said C-mannosylated CMT sbstrate on the surface of said cell.
(FR)Cette invention a trait à des criblages axés sur des cellules et permettant de déceler une activité de la C-Mannosyltransférase (CMT) ainsi qu'à des criblages destinés à rechercher des agents modulant efficacement l'activité de la CMT.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)