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1. (WO2004033703) NOVEL MACROPHAGE FOAM CELL FORMATION INHIBITOR FKA−25 AND PROCESS FOR PRODUCING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/033703    International Application No.:    PCT/JP2002/010585
Publication Date: 22.04.2004 International Filing Date: 11.10.2002
Chapter 2 Demand Filed:    07.11.2002    
IPC:
C07D 405/06 (2006.01), C12P 17/16 (2006.01)
Applicants: THE KITASATO INSTITUTE [JP/JP]; 9-1, Shirokane 5-chome, Minato-ku, Tokyo 108-8642 (JP) (For All Designated States Except US).
OMURA, Satoshi [JP/JP]; (JP) (For US Only).
TOMODA, Hiroshi [JP/JP]; (JP) (For US Only).
MASUMA, Rokuro [JP/JP]; (JP) (For US Only)
Inventors: OMURA, Satoshi; (JP).
TOMODA, Hiroshi; (JP).
MASUMA, Rokuro; (JP)
Agent: KOBAYASHI, Kazunori; Taiyoseimeiotsuka Bldg. 3F, 25-1, Kitaotsuka 2-chome, Toshima-ku, Tokyo 170-0004 (JP)
Priority Data:
Title (EN) NOVEL MACROPHAGE FOAM CELL FORMATION INHIBITOR FKA−25 AND PROCESS FOR PRODUCING THE SAME
(FR) NOUVEL INHIBITEUR DE LA FORMATION DE CELLULES SPUMEUSES DE MACROPHAGES ET PROCEDE DE PRODUCTION DE CELUI-CI
(JA) 新規マクロファージ泡沫化阻害物質FKA−25およびその製造法
Abstract: front page image
(EN)A novel macrophage foam cell formation inhibitor FKA−25 which is a substance inhibiting the formation of mouse−origin macrophage foam cells. Pseudobotrytis sp. FKA−25, which is a strain belonging to the genus Pseudobotrytis and capable of producing FKA−25, is cultured in a medium to accumulate FKA−25 in the culture medium and then the FKA−25 is collected from the culture medium. Because of specifically inhibiting the formation of mouse−origin macrophage foam cells, the thus obtained FKA−25 is expected as being useful in preventing and treating arteriosclerosis and diseases caused thereby.
(FR)L'invention concerne un nouvel inhibiteur de la formation de cellules spumeuses de macrophages, FKA-25, qui est une matière inhibant la formation de cellules spumeuses de macrophages de souris. Pseudobotrytis sp. FKA-25, une souche appartenant au genre Pseudobotrytis et qui peut produire FKA-25, est cultivée dans un milieu de culture permettant l'accumulation de FKA-25, cette matière étant ensuite extraite dudit milieu. En raison de sa capacité à inhiber spécifiquement la formation de cellules spumeuses de macrophages de souris, FKA-25 est susceptible d'être utile dans la prévention et le traitement de l'artériosclérose et de maladies engendrées par celle-ci.
(JA)本発明は、マウス由来のマクロファージ泡沫化を阻害する新規マクロファージ泡沫化阻害物質FKA-25物質およびその製造法であり、シュードボトリティス属に属する、FKA-25物質を生産する能力を有するシュードボトリティス エスピー FKA-25を培地に培養し、その培養物中にFKA-25物質を蓄積せしめ、該培養物からFKA-25物質を採取される。得られたFKA-25物質はマウス由来のマクロファージの泡沫化を特異的に阻害することから動脈硬化症やそれに起因する疾病の予防および治療に有用であると期待される。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)