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1. (WO2004033687) METHOD OF SCREENING REMEDY FOR RENAL FAILURE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/033687    International Application No.:    PCT/JP2003/012967
Publication Date: 22.04.2004 International Filing Date: 09.10.2003
Chapter 2 Demand Filed:    24.02.2004    
IPC:
A61K 38/00 (2006.01), C07K 14/705 (2006.01), G01N 33/68 (2006.01)
Applicants: YAMANOUCHI PHARMACEUTICAL CO., LTD. [JP/JP]; 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo 103-8411 (JP) (For All Designated States Except US).
ENJO, Kentaro [JP/JP]; (JP) (For US Only).
KUROMITSU, Sadao [JP/JP]; (JP) (For US Only)
Inventors: ENJO, Kentaro; (JP).
KUROMITSU, Sadao; (JP)
Agent: NAGAI, Shozo; c/o Yamanouchi Pharmaceutical Co., Ltd., Patent Department, 17-1, Hasune 3-chome, Itabashi-ku, Tokyo 174-8612 (JP)
Priority Data:
2002-298958 11.10.2002 JP
Title (EN) METHOD OF SCREENING REMEDY FOR RENAL FAILURE
(FR) PROCEDE DE CRIBLAGE D'UN MEDICAMENT CONTRE L'INSUFFISANCE RENALE
(JA) 腎不全治療薬をスクリーニングする方法
Abstract: front page image
(EN)A screening tool for obtaining a remedy for renal failure, a convenient screening method, a medicinal composition for treating renal failure and a process for producing the same. The screening tool as described above comprises a G protein-coupled receptor FGK which is a polypeptide capable of activating CTGF promoter, a functionally equivalent modification thereof, a polypeptide homologous with it or cells expressing the above polypeptide. In the above screening method, the inhibition of the above-described polypeptide is employed as an indication.
(FR)Cette invention porte sur un instrument de criblage permettant d'obtenir un médicament contre l'insuffisance rénale, sur une méthode de criblage appropriée, sur une composition thérapeutique permettant de traiter l'insuffisance rénale ainsi que sur un procédé de production de cette composition. L'instrument de criblage de cette invention comprend un récepteur FGK couplé à la protéine G qui est un polypeptide capable d'activer un promoteur CTGF, une modification fonctionnellement équivalente de celui-ci, un polypeptide homologue de celui-ci ou des cellules exprimant ledit polypeptide. Dans la méthode de criblage susmentionnée, l'inhibition du polypeptide sert d'indication.
(JA)腎不全治療薬を得るためのスクリーニングツール及び簡便なスクリーニング方法、並びに腎不全治療用医薬組成物及びその製造方法を開示する。前記スクリーニングツールはCTGFプロモーターを活性化することができるポリペプチドであるG蛋白質共役型受容体FGK、その機能的等価改変体、又は相同ポリペプチドであるか、あるいは前記ポリペプチドを発現している細胞である。スクリーニング方法は、前記ポリペプチドの阻害を指標とする方法である。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)