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1. (WO2004033638) COMPOSITIONS, ORGANISMS AND METHODOLOGIES EMPLOYING A NOVEL HUMAN KINASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/033638    International Application No.:    PCT/US2003/031591
Publication Date: 22.04.2004 International Filing Date: 07.10.2003
Chapter 2 Demand Filed:    15.04.2004    
IPC:
C12N 9/12 (2006.01)
Applicants: WYETH [US/US]; 5 Giralda Farms, Madison, NJ 07940 (US) (For All Designated States Except US).
LIU, Wei [CN/US]; (US) (For US Only).
WU, Leeying [US/US]; (US) (For US Only)
Inventors: LIU, Wei; (US).
WU, Leeying; (US)
Agent: VAN DYKE, Raymond; Nixon Peabody LLP, 401 9th Street N.W., Washington, DC 20004 (US)
Priority Data:
60/416,257 07.10.2002 US
Title (EN) COMPOSITIONS, ORGANISMS AND METHODOLOGIES EMPLOYING A NOVEL HUMAN KINASE
(FR) COMPOSITIONS, ORGANISMES ET PROCEDES UTILISANT UNE NOUVELLE PROTEINE KINASE HUMAINE
Abstract: front page image
(EN)This invention provides compositions, organisms and methodologies employing a novel human protein kinase, MCRK2. The novel human kinase has sequence homology to rat myotonic dystrophy kinase-related Cdc42 binding kinase (MRCK) alpha. The gene encoding the novel kinase is localized in locus 1q42 of human chromosome 1. The novel protein kinase comprises multiple functional/structural domains that include a kinase domain, a pkinase_C domain, a DAG-PE binding domain, and a CNH domain. The sequence and structure similarity between the novel human protein and rat MRCK alpha indicates that the novel human protein may function as a downstream effector of Cdc42 in cytoskeleton reorganization.
(FR)L'invention concerne des compositions, des organismes et des procédés utilisant une nouvelle protéine kinase humaine, MCRK2. Cette nouvelle kinase humaine possède une homologie de séquence avec la kinase de liaison avec Cdc42 liée à la kinase (MRCK) alpha de la dystrophie myotonique du rat. Le gène codant la nouvelle kinase se trouve dans le locus 1q42 du chromosome humain 1. Cette nouvelle protéine kinase comprend plusieurs domaines fonctionnels/structurels qui comportent un domaine kinase, un domaine pkinase_C, un domaine de liaison DAG-PE, et un domaine CNH. La similarité de séquence et de structure entre la nouvelle protéine humaine et MRCK alpha du rat indiquent que la nouvelle protéine humaine peut fonctionner en tant qu'effecteur aval de Cdc42 dans la réorganisation du cytosquelette.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)