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1. (WO2004033496) AGONISTS AND ANTAGONISTS OF THE HUMAN ODORANT RECEPTOR OR17-4 AND USES THEREOF

Pub. No.:    WO/2004/033496    International Application No.:    PCT/EP2003/010915
Publication Date: Apr 22, 2004 International Filing Date: Oct 2, 2003
IPC: A61K 31/11
C07K 14/705
Applicants: SYMRISE GMBH & CO. KG
HATT, Hanns
Inventors: HATT, Hanns
Title: AGONISTS AND ANTAGONISTS OF THE HUMAN ODORANT RECEPTOR OR17-4 AND USES THEREOF
Abstract:
The invention relates to the field of olfactory receptors, conception-influencing medicaments, and biosensors. Disclosed are receptors having a section of the human hOR17-4 gene and receptor proteins that are derived therefrom. Also disclosed are receptors for detecting phenylacetaldehyde, 3-phenylpropanal, 3- phenylbutyraldehyde, 4-phenylbutyraldehyde, canthoxal, cyclamal, floralazone, bourgeonal, lilial, and (4-tert-butylphenoxy)acetaldehyde (agonists). The invention further relates to receptors for said substances, which can be inhibited by applying antagonists, especially n-undecanal. The invention finally relates to advantageous uses of said receptors, agonists, and antagonists.