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1. (WO2004033440) THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/033440    International Application No.:    PCT/US2003/031707
Publication Date: 22.04.2004 International Filing Date: 07.10.2003
Chapter 2 Demand Filed:    23.04.2004    
IPC:
C07D 285/10 (2006.01), C07D 417/12 (2006.01), C07D 417/14 (2006.01)
Applicants: SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road, Kenilworth, NJ 07033-0530 (US).
PHARMACOPEIA DRUG DISCOVERY, INC. [US/US]; 3000 Eastpark Boulevard, Cranbury, NJ 08512 (US)
Inventors: TAVERAS, Arthur, G.; (US).
CHAO, Jianhua; (US).
BIJU, Purakkattle, J.; (US).
YU, Younong; (US).
FINE, Jay, S.; (US).
HIPKIN, William; (US).
AKI, Cynthia, J.; (US).
MERRITT, J., Robert; (US).
LI, Ge; (CN).
BALDWIN, John, J.; (US).
LAI, Gaifa; (US).
WU, Minglang; (US).
HECKER, Evan, A.; (US)
Agent: JEANETTE, Henry, C.; Schering-Plough Corporation, Patent Department - K-6-1 1990, 2000 Galloping Hill Road, Kenilworth, NJ 07033-0530 (US)
Priority Data:
60/417,371 09.10.2002 US
Title (EN) THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS
(FR) THIADIAZOLEDIOXYDES ET THIADIAZOLEOXIDES CONVENANT COMME LIGANDS DES RECEPTEURS DES CXC- ET CC-CHIMIOKINES
Abstract: front page image
(EN)Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).
(FR)La présente invention concerne de nouveaux composés représentés par la formule générale (IA) et certains de ses sels et solvates pharmaceutiquement admis. Avec le substituant A, il s'agit essentiellement de groupes hétéroaryle, aryle, hétérocycloalkyle, cycloalkyle, aryle, alkynyle, alcényle, aminoalkyle, alkyle ou amino. Avec le substituant B, il s'agit essentiellement de groupes aryle et hétéroaryle. L'invention concerne également un procédé permettant de traiter, par administration d'un composé représenté par la formule générale (IA), des maladies où intervient une médiation chimiokinique telle que cancer, angiogenèse, maladies oculaires angiogènes, maladies pulmonaires, sclérose en plaques, arthrite rheumatoïde, arthrose, lésions d'accidents cérébrovasculaires et de reperfusion, douleur aiguë, douleur inflammatoire aiguë et chronique, et douleur neuropathique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, HR, HU, ID, IL, IN, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LU, LV, MA, MD, MG, MK, MN, MX, MZ, NI, NO, NZ, PG, PH, PL, PT, RO, RU, SC, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UZ, VC, VN, YU, ZA, ZM.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)