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1. (WO2004033439) THIAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/033439    International Application No.:    PCT/IB2003/004330
Publication Date: 22.04.2004 International Filing Date: 29.09.2003
Chapter 2 Demand Filed:    21.11.2003    
IPC:
C07D 277/46 (2006.01), C07D 277/54 (2006.01), C07D 277/56 (2006.01), C07D 277/60 (2006.01), C07D 277/82 (2006.01), C07D 417/04 (2006.01), C07D 417/06 (2006.01), C07D 417/12 (2006.01)
Applicants: PFIZER PRODUCTS INC. [US/US]; Eastern Point Road, Groton, CT 06340 (US) (For All Designated States Except US).
CHEN, Yuhpyng, Liang [US/US]; (US) (For US Only).
CORMAN, Michael, Leon [US/US]; (US) (For US Only)
Inventors: CHEN, Yuhpyng, Liang; (US).
CORMAN, Michael, Leon; (US)
Agent: LUMB, J., Trevor; Pfizer Inc., 201 Tabor Road, Morris Plains, NJ 07950 (US)
Priority Data:
60/417,400 09.10.2002 US
10/463,209 17.06.2003 US
Title (EN) THIAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
(FR) COMPOSES THIAZOLE UTILES POUR LE TRAITEMENT DES MALADIES NEURODEGENERATIVES
Abstract: front page image
(EN)The invention provides compounds of Formula (I): wherein R1, R2, R3, R4, R6, R7, and A are as defined. Compounds of Formula (I) have activity inhibiting production of Aß-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula (I).
(FR)La présente invention concerne des composés représentés par la formule (I) dans laquelle R', R2, R3, R4, R6, R' et A sont tels que définis dans le descriptif. Les composés représentés par la formule (I) présentent une activité d'inhibition de la production du peptide Aß. La présente invention concerne également des compositions pharmaceutiques et des méthodes de traitement de maladies, telles que par exemple la maladie d'Alzheimer, chez des mammifères, qui comprennent des composés de formule (I). Formule (I)
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)