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1. (WO2004033438) NOVEL HETEROCYCLIC ANALOGS OF DIPHENYLETHYLENE COMPOUNDS

Pub. No.:    WO/2004/033438    International Application No.:    PCT/US2003/031803
Publication Date: Apr 22, 2004 International Filing Date: Oct 8, 2003
IPC: C07D 277/20
C07D 277/34
Applicants: THERACOS, INC.
NEOGI, Partha
DEY, Debendranath
MEDICHERLA, Satyanarayana
NAG, Biswajit
LEE, Arthur
Inventors: NEOGI, Partha
DEY, Debendranath
MEDICHERLA, Satyanarayana
NAG, Biswajit
LEE, Arthur
Title: NOVEL HETEROCYCLIC ANALOGS OF DIPHENYLETHYLENE COMPOUNDS
Abstract:
Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.