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1. (WO2004032965) ENDOGENOUS REPAIR FACTOR PRODUCTION PROMOTERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/032965    International Application No.:    PCT/JP2003/012981
Publication Date: 22.04.2004 International Filing Date: 09.10.2003
Chapter 2 Demand Filed:    09.04.2004    
IPC:
A61K 9/16 (2006.01), A61K 31/19 (2006.01), A61K 31/343 (2006.01), A61K 31/403 (2006.01), A61K 31/4406 (2006.01)
Applicants: ONO PHARMACEUTICAL CO., LTD. [JP/JP]; 1-5, Doshomachi 2-chome, Chuo-ku, Osaka-shi, Osaka 541-8526 (JP) (For All Designated States Except US).
SAKAI, Yoshiki [JP/JP]; (JP) (For US Only).
NISHIURA, Akio [JP/JP]; (JP) (For US Only).
OGATA, Teppei [JP/JP]; (JP) (For US Only)
Inventors: SAKAI, Yoshiki; (JP).
NISHIURA, Akio; (JP).
OGATA, Teppei; (JP)
Agent: OHIE, Kunihisa; Ohie Patent Office, Selva-Ningyocho 6F, 14-6, Nihonbashi-Ningyocho 2-chome, Chuo-ku, Tokyo 103-0013 (JP)
Priority Data:
2002-298079 10.10.2002 JP
2002-318830 31.10.2002 JP
2003-117604 22.04.2003 JP
Title (EN) ENDOGENOUS REPAIR FACTOR PRODUCTION PROMOTERS
(FR) PROMOTEURS DE PRODUCTION DE FACTEURS DE REPARATION ENDOGENES
(JA) 内因性修復因子産生促進剤
Abstract: front page image
(EN)Promoters for the production of endogenous repair factors containing one or more members selected from among prostaglandin (PG) I2 agonist, EP2 agonist and EP4 agonist. Because of being capable of promoting the production of various endogenous repair factors and having effects of promoting angiogenesis and inducing stem cell differentiation, prostaglandin (PG) I2 agonist, EP2 agonist and EP4 agonist are useful in preventing and treating ischemic organ failures (arteriosclerosis obliterans, Buerger’s disease, Raynaud’s disease, myocardial infarction, angina, diabetic neuropathy, vertebral stenosis, cerebrovascular disorders, brain infarction, pulmonary hypertension, bone fracture, Alzheimer’s disease, etc.).
(FR)La présente invention concerne des promoteurs de production de facteurs de réparation endogènes contenant au moins un élément du groupe de l'agoniste I2 de la prostaglandine (PG), de l'agoniste EP2 et de l'agoniste EP4. Capables de favoriser la production de divers facteurs de réparation endogènes, favorisant l'angiogenèse, et induisant la différentiation des cellules souches, l'agoniste I2 de la prostaglandine (PG), l'agoniste EP2 et de l'agoniste EP4 conviennent particulièrement à la prévention et au traitement des défaillances d'organes ischémiques (artériosclérose oblitérante, thromboangéite oblitérante, maladie de Raynaud, infarctus du myocarde, angine de poitrine, neuropathie diabétique, sténose vertébrale, troubles cérébro-vasculaires, infarctus cérébral, hypertension pulmonaire, fracture osseuse, maladie d'Alzheimer, etc.).
(JA)プロスタグランジン(PG)I2アゴニスト、EP2アゴニストおよびEP4アゴニストから選択される1種または2種以上を含有する内因性修復因子産生促進剤に関する。プロスタグランジン(PG)I2アゴニスト、EP2アゴニストまたはEP4アゴニストは各種内因性修復因子産生促進作用があり、血管新生促進作用や幹細胞分化誘導作用を有するため、虚血性臓器障害(閉塞性動脈硬化症、バージャー病、レイノー病、心筋梗塞、狭心症、糖尿病性神経障害、脊柱管狭窄症、脳血管障害、脳梗塞、肺高血圧症、骨折またはアルツハイマー病等)、および各種細胞・臓器障害等の予防や治療に有用である。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)