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1. (WO2004032832) BISPECIFIC MOLECULE COMPRISING AN ANTI-CR1 ANTIBODY CROSS-LINKED TO AN ANTIGEN-BINDING ANTIBODY FRAGMENT

Pub. No.:    WO/2004/032832    International Application No.:    PCT/US2003/029065
Publication Date: Fri Apr 23 01:59:59 CEST 2004 International Filing Date: Wed Sep 17 01:59:59 CEST 2003
IPC: C07K 16/12
C07K 16/28
Applicants: ELUSYS THERAPEUTICS, INC.
MOHAMED, Nehal
CASEY, Leslie
PORTER, James, P.
WANG, Xiaoliang
SESAY, Muctarr
LEE, Lihsyng, Stanford
Inventors: MOHAMED, Nehal
CASEY, Leslie
PORTER, James, P.
WANG, Xiaoliang
SESAY, Muctarr
LEE, Lihsyng, Stanford
Title: BISPECIFIC MOLECULE COMPRISING AN ANTI-CR1 ANTIBODY CROSS-LINKED TO AN ANTIGEN-BINDING ANTIBODY FRAGMENT
Abstract:
The invention provides a bispecific molecule comprising an antibody that binds a C3b-like to one or more antigen-binding antibody fragments, each of which binds an antigenic molecule. The invention also provides methods of producing such bispecific molecules and to therapeutic uses of such bispecific molecules. The invention further provides bispecific molecules in which the antigen-binding antibody fragment binds the protective antigen protein of Bacillus anthracis (Anthrax) exotoxin for treatment of Anthrax infection.