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1. (WO2004031180) QUINAZOLIN-4-ONE DERIVATIVES

Pub. No.:    WO/2004/031180    International Application No.:    PCT/JP2003/012648
Publication Date: Apr 15, 2004 International Filing Date: Oct 2, 2003
IPC: C07D 403/12
Applicants: INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC.

ITAI, Akiko

MUTO, Susumu

INOUE, Tsuyoshi

URADE, Yoshihiro

Inventors: ITAI, Akiko

MUTO, Susumu

INOUE, Tsuyoshi

URADE, Yoshihiro

Title: QUINAZOLIN-4-ONE DERIVATIVES
Abstract:
Drugs having inhibitory activity against hematopoietic prostaglandin D2 synthase, containing as the active ingredient compounds represented by the general formula (I) or salts thereof: (I) wherein X is -N=C(R5)- or -NH-CH(R5)-; R1, R2, R3, and R4 are each hydrogen, halogeno, C1-6 alkyl, or hydroxyl; R5 is C1-6 alkyl or C6-10 aryl; and R is amino.