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Machine translation
1. (WO2004031169) ANTIBACTERIAL AGENT HAVING THIOPHENE SKELETON
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/031169    International Application No.:    PCT/JP2002/010366
Publication Date: 15.04.2004 International Filing Date: 04.10.2002
Chapter 2 Demand Filed:    08.05.2003    
IPC:
A61K 31/381 (2006.01), A61K 31/4365 (2006.01), C07D 333/68 (2006.01), C07D 495/04 (2006.01)
Applicants: RRF RESEARCH INC. [JP/JP]; c/o Tsukuba Laboratories, Hisamitsu Pharmaceutical Co., Inc., 25-14, Kannondai 1-Chome, Tsukuba-Shi, Ibaraki 305-0856 (JP) (For All Designated States Except US).
IKESUE, Koichi [JP/JP]; (JP) (For US Only).
YOSHIDA, Toshio [JP/JP]; (JP) (For US Only).
YASUDA, Minoru [JP/JP]; (JP) (For US Only).
MAEDA, Yutaka [JP/JP]; (JP) (For US Only).
NAKASHIMA, Mihoko [JP/JP]; (JP) (For US Only).
YOKOSE, Kazuteru [JP/JP]; (JP) (For US Only).
HARA, Hiroto [JP/JP]; (JP) (For US Only)
Inventors: IKESUE, Koichi; (JP).
YOSHIDA, Toshio; (JP).
YASUDA, Minoru; (JP).
MAEDA, Yutaka; (JP).
NAKASHIMA, Mihoko; (JP).
YOKOSE, Kazuteru; (JP).
HARA, Hiroto; (JP)
Agent: NAKAMURA, Minoru; Shin-Tokyo Bldg., 3-1, Marunouchi 3-Chome, Chiyoda-Ku, Tokyo 100-8355 (JP)
Priority Data:
Title (EN) ANTIBACTERIAL AGENT HAVING THIOPHENE SKELETON
(FR) AGENT ANTIBACTERIEN A SQUELETTE DE THIOPHENE
(JA) チオフェン骨格を有する抗菌剤
Abstract: front page image
(EN)A compound having a thiophene skeleton which has excellent antibacterial activity against gram−positive bacteria and resistant gram−positive bacteria. The compound having a thiophene skeleton is represented by the following formula: (I) wherein X is =CH−R8, =C(R8)2, =CO, =C=N−R11, −O−, −S−, or =N−R11; R1, R2, R3, R4, and R5 each independently is hydrogen, halogeno, amino, nitro, lower alkyl, or lower alkoxy; R6, R7, R8, and R9 each independently is hydrogen, hydroxy, lower alkyl, lower alkoxy, or phenyl, provided that when two R6, R7, R8, or R9 substituents are present on the same carbon atom, these substituents may be the same or different; R10 is halogenated lower alkyl; R11 is hydrogen, hydroxy, lower alkyl, lower alkoxy, alkanoyl, benzoyl, (lower alkyloxy)carbonyl, (lower alkyl)sulfonyl, benzenesulfonyl, or benzyloxycarbonyl; and n is 1 or 2.
(FR)L'invention porte sur un composé à squelette de thiophène à forte activité antibactérienne vis-à-vis des bactéries gram-positives et des bactéries gram-positives résistantes. Ledit composé, présente la formule (I) dans laquelle: X est =CH-R8, =C(R8)2, =CO, =C=N-R11, -O-, -S-, ou =N-R11; R1, R2, R3, R4, et R5 sont chacun indépendamment H, halogéno, amino, nitro, alkyle inférieur ou alkoxy inférieur; R6, R7, R8, et R9 sont chacun indépendamment H, hydroxy, alkyle inférieur, alkoxy inférieur ou phényle, sous réserve que si deux des substituants R6, R7, R8, ou R9 sont présents sur le même atome de carbone, ils puissent être identiques ou différents; R10 est halogéno-alkyle inférieur; R11 est H, hydroxy, alkyle inférieur, alkoxy inférieur, alkanoyle, benzoyle, (alkyloxy inférieur)carbonyle, (alkyle inférieur)sulfonyle, benzènesulfonyle, ou benzyloxycarbonyle; et n est 1 ou 2.
(JA)not available
Designated States: CN, US.
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)