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1. (WO2004030511) PROSTATE CANCER BIOMARKERS

Pub. No.:    WO/2004/030511    International Application No.:    PCT/US2003/014432
Publication Date: Apr 15, 2004 International Filing Date: May 9, 2003
IPC: A61B 1/00
Applicants: EASTERN VIRGINIA MEDICAL SCHOOL
FRED HUTCHINSON CANCER RESEARCH CENTER
WRIGHT, George, L., Jr.
ADAM, Bao-Ling
QU, Yinsheng
Inventors: WRIGHT, George, L., Jr.
ADAM, Bao-Ling
QU, Yinsheng
Title: PROSTATE CANCER BIOMARKERS
Abstract:
Protein biomarkers that may advantageously be utilized in diagnosing prostate cancer, benign prostate hyperplasia or to make a negative diagnosis are described. Accordingly, in one aspect of the invention, methods for aiding in, or otherwise making, a diagnosis of prostate cancer or benign prostate hyperplasia are provided. In one form of the invention, a method includes detecting various protein biomarkers of defined molecular weight and correlating the detection to a diagnosis of prostate cancer, benign prostate hyperplasia or to a negative diagnosis. In yet another aspect of the invention, kits are provided that may be utilized to detect the biomarkers described herein. In a further of the invention, methods of using a plurality of classifiers to make a probable diagnosis of prostate cancer of benign prostate hyperplasia are provided. In certain forms of the invention, the methods include use of a boosted decision tree analysis. Various computer readable media are also provided.