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1. (WO2004029622) ANTIBODY TOOLS FOR THE DIAGNOSTIC USE IN THE MEDICAL THERAPY WITH INHIBITORS OF HISTONE DEACETYLASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/029622    International Application No.:    PCT/EP2003/010842
Publication Date: 08.04.2004 International Filing Date: 30.09.2003
IPC:
C07K 16/18 (2006.01), C12Q 1/44 (2006.01)
Applicants: G2M CANCER DRUGS AG [DE/DE]; Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt am Main (DE) (For All Designated States Except US).
PELICCI, Pier, Giuseppe [IT/IT]; (IT) (For US Only).
MINUCCI, Saverio [IT/IT]; (IT) (For US Only).
PICCINI, Daniele [IT/IT]; (IT) (For US Only).
MACCARANA, Marco [IT/IT]; (IT) (For US Only).
RONZONI, Simona [IT/IT]; (IT) (For US Only).
ARECES, Liliana, Beatriz [IT/IT]; (IT) (For US Only).
FARETTA, Mario [IT/IT]; (IT) (For US Only)
Inventors: PELICCI, Pier, Giuseppe; (IT).
MINUCCI, Saverio; (IT).
PICCINI, Daniele; (IT).
MACCARANA, Marco; (IT).
RONZONI, Simona; (IT).
ARECES, Liliana, Beatriz; (IT).
FARETTA, Mario; (IT)
Agent: KELLER, Günter; LEDERER & KELLER, Prinzregentenstrasse 16, 80538 München (DE)
Priority Data:
02021984.6 30.09.2002 EP
Title (EN) ANTIBODY TOOLS FOR THE DIAGNOSTIC USE IN THE MEDICAL THERAPY WITH INHIBITORS OF HISTONE DEACETYLASES
(FR) OUTILS A BASE D'ANTICORPS DESTINES AU DIAGNOSTIC DANS LE TRAITEMENT MEDICAL AVEC DES INHIBITEURS D'HISTONE DESACETYLASES
Abstract: front page image
(EN)The invention relates to a method for determining whether a treatment of a disorder with an HDAC inhibitor is to be started/continued or not comprising determining the level of histone acetylation in the sample by use of an antibody capable of binding to acetylated histone, and classifying the disorder as to be treated with an HDAC inhibitor when the level of histone acetylation is significantly lower than that of a reference sample. The invention further relates to the diagnostic and prognostic use of specific antibodies and cell lines producing them.
(FR)L'invention concerne un procédé destiné à déterminer si un traitement d'un trouble avec un inhibiteur HDAC doit être commencé/continué ou à exclure la détermination du niveau d'acétylation d'histone dans l'échantillon par utilisation d'un anticorps capable de se lier à l'histone acétylé, et à classifier le trouble à traiter avec un inhibiteur HDAC lorsque le niveau d'acétylation d'histone est sensiblement inférieur à celui d'un échantillon de référence. L'invention concerne enfin l'utilisation d'anticorps spécifiques dans le diagnostic et le pronostic ainsi que des lignées cellulaires produisant ces anticorps.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)