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Machine translation
1. (WO2004029213) COMPOSITIONS AND METHODS FOR DELIVERY OF SHORT INTERFERING RNA AND SHORT HAIRPIN RNA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/029213    International Application No.:    PCT/US2003/030508
Publication Date: 08.04.2004 International Filing Date: 29.09.2003
IPC:
A61K 38/00 (2006.01), C12N 15/11 (2006.01)
Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; Five Cambridge Center, Cambridge, MA 02142-1493 (US) (For All Designated States Except US).
CHEN, Jianzhu [US/US]; (US) (For US Only).
EISEN, Herman, N. [US/US]; (US) (For US Only).
GE, Qing [CN/US]; (US) (For US Only)
Inventors: CHEN, Jianzhu; (US).
EISEN, Herman, N.; (US).
GE, Qing; (US)
Agent: GERBER, Monica, R.; Choate, Hall & Stewart, Exchange Place, 53 State Street, Boston, MA 02109 (US)
Priority Data:
60/414,457 28.09.2002 US
60/446,377 10.02.2003 US
Title (EN) COMPOSITIONS AND METHODS FOR DELIVERY OF SHORT INTERFERING RNA AND SHORT HAIRPIN RNA
(FR) COMPOSITIONS ET METHODES DE TRANSMISSION D'ARN INTERFERANT COURT ET D'ARN INTERFERANT COURT EN FORME D'EPINGLE A CHEVEUX
Abstract: front page image
(EN)The present invention provides compositions comprising an RNAi-inducing entity any of a variety of different delivery agents. Preferred RNAi-inducing agents include siRNA, shRNA, and RNAi-inducing vectors. Preferred delivery agents include cationic polymers, modified cationic polymers, lipids, and surfactants suitable for introduction into the lung. The invention further provides methods of inhibiting expression of a target 10 transcript in a mammal and methods of treating or preventing a disease or condition in a mammal by administration of the compositions.
(FR)La présente invention concerne des compositions comprenant une entité activatrice de RNAi d'un agent quelconque d'une gamme de différents agents de transmission. Des agents préférés d'activation de RNAi comprennent des vecteurs de siRNA, de shRNA, et de RNAi. Des agents de transmission préférés comprennent des polymères cationiques, des polymères cationiques modifiés, des lipides et des tensioactifs appropriés pour une introduction dans le poumon. L'invention concerne en outre des méthodes pouvant inhiber l'expression d'un transcrit cible chez un mammifère, et des méthodes pour traiter ou prévenir une maladie ou une affection chez un mammifère, par administration des compositions de l'invention.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)