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1. (WO2004029197) CO-STIMULATORY MOLECULES

Pub. No.:    WO/2004/029197    International Application No.:    PCT/US2002/019898
Publication Date: Apr 8, 2004 International Filing Date: Jun 21, 2002
IPC: A61K 38/00
C07K 14/705
Applicants: MAXYGEN, INC.
PUNNONEN, Juha
LAZETIC, Alexandra, L., L.
LEONG, Steven, R.
CHANG, Jean, Chia-Chun
APT, Doris
GUSTAFSSON, Claes
Inventors: PUNNONEN, Juha
LAZETIC, Alexandra, L., L.
LEONG, Steven, R.
CHANG, Jean, Chia-Chun
APT, Doris
GUSTAFSSON, Claes
Title: CO-STIMULATORY MOLECULES
Abstract:
The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a human CD28 or CTLA-4 receptor at a level greater or less than the ability of human B7-1 to bind human CD28 or CTLA-4, or to induce or inhibit altered level of T cell proliferation response greater compared to that generated by human B7-1. The polypeptides and polynulceotides of the invention are useful in therapeutic and prophylactic treatment methods, gene therapy applications, and vaccines.