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1. (WO2004028540) ANTI-NEURODEGENERATIVE AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/028540    International Application No.:    PCT/JP2003/012540
Publication Date: 08.04.2004 International Filing Date: 30.09.2003
Chapter 2 Demand Filed:    13.02.2004    
IPC:
A61K 31/454 (2006.01), A61K 31/495 (2006.01), A61K 31/496 (2006.01), C07D 471/04 (2006.01)
Applicants: IKEDA, Joh-E [JP/JP]; (JP).
OKADA, Yoshinori [JP/JP]; (JP) (For US Only).
SAKAI, Harumi [JP/JP]; (JP) (For US Only).
OSUGA, Hitoshi [JP/JP]; (JP) (For US Only)
Inventors: IKEDA, Joh-E; (JP).
OKADA, Yoshinori; (JP).
SAKAI, Harumi; (JP).
OSUGA, Hitoshi; (JP)
Agent: NISHIZAWA, Toshio; Three F Minami Aoyama Bldg. 7F,, 11-1, Minami-Aoyama 6-chome,, Minato-ku, Tokyo 107-0062 (JP)
Priority Data:
2002-286400 30.09.2002 JP
Title (EN) ANTI-NEURODEGENERATIVE AGENTS
(FR) AGENTS ANTINEURODEGENERATIFS
(JA) 抗神経変性薬
Abstract: front page image
(EN)An anti-neurodegenerative agent useful in treating and preventing neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), Huntinton’s disease, Parkinson’s disease, Alzheimer’s disease, dementia following cerebrovascular accident and other dementias associated with nerve loss which contains one or more compounds selected from the group consisting of 3-[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine or its salt, 5-(4-chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole or its salt, 3-(4-chlorophenyl)-4-methyl-5-(1-(2-phenylethyl)piperidin-4-yl)isoxazole or its salt, and N-methyl-4-(2-cyanophenyl)piperazinyl-3-methylbenzamine or its salt.
(FR)L'invention concerne un agent antineurodégénératif utile pour traiter et prévenir des maladies neurodégénératives telles que la sclérose latérale amyotrophique, l'amyotrophie spinale, la maladie de Huntington, la maladie de Parkinson, la maladie d'Alzheimer, la démence consécutive à un accident vasculaire cérébral et d'autres démences associées à une perte neuronale. Cet agent contient un ou plusieurs composés sélectionnés dans le groupe constitué par 3-[4-chlorophényl)pipérazine-1-yl]méthyl]-1H-pyrrolo[2,3-b]pyridine ou son sel, 5-(4-chlorophényl)-4-méthyl-3-(1-(2-phényléthyl)pipéridine-4-yl)isoxazole ou son sel, 3-(4-chlorophényl)-4-méthyl-5(1-(2-phényléthyl)pipéridine-4-yl)isoxazole ou son sel et N-méthyl-4-(2-cyanophényl)pipérazinyl-3-méthylbenzamine ou son sel.
(JA)筋萎縮性側索硬化症(ALS)、脊髄性筋萎縮症候群(SMA)、ハンチントン病、パーキンソン病、アルツハイマー病、脳血管障害後の痴呆、その他の神経脱落を伴う痴呆症等の神経変性疾患の治療及び予防に有用な薬剤であって、3-[4-(4-クロロフェニル)ピペラジン-1-イル]メチル]-1H-ピロロ[2,3-b]ピリジン又はその塩、5-(4-クロロフェニル)-4-メチル-3-(1-(2-フェニルエチル)ピペリジン-4-イル)イソキサゾール又はその塩、3-(4-クロロフェニル)-4-メチル-5-(1-(2-フェニルエチル)ピペリジン-4-イル)イソキサゾール又はその塩、及びN-メチル-4-(2-シアノフェニル)ピペラジニル-3-メチルベンズアミン又はその塩、からなる群より選択される1種または2種以上の化合物を含む抗神経変性薬。
Designated States: CA, US.
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)