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1. (WO2004028466) KETOAMIDE INHIBITORS IN CHRONIC NERVE DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/028466    International Application No.:    PCT/US2003/030449
Publication Date: 08.04.2004 International Filing Date: 25.09.2003
IPC:
A61K 38/00 (2006.01)
Applicants: GEORIGA TECH RESEARCH CORPORATION [US/US]; 505 Tenth Street, N.W., Atlanta, GA 30332 (US)
Inventors: POWERS, James, C.; (US).
GLASS, Jonathan, D.; (US)
Agent: VORNDRAN, Charles; Thomas, Kayden, Horstemeyer & Risley, LLP, 100 Galleria Parkway, Suite 1750, Atlanta, GA 30339 (US)
Priority Data:
60/413,506 25.09.2002 US
Title (EN) KETOAMIDE INHIBITORS IN CHRONIC NERVE DISEASE
(FR) INHIBITEURS DE CETOAMIDES DANS LES MALADIES NERVEUSES CHRONIQUES
Abstract: front page image
(EN)Compositions and methods for treating neural pathologies are provided. In particular, compositions and methods for treating neural pathologies including axonal degeneration are provided. The compositions include peptide &agr;-ketomides optionally in combination with a second therapeutic agent. Another aspect of the invention provides compositions and methods for treating hyperproliferative disorders. Exemplary compositions for treating hyperproliferative disorders include an antiproliferative agent such as paclitaxel, in combination with a calpain inhibitor such as AK295.
(FR)L'invention porte sur des compositions et sur des méthodes de traitement de pathologies neuronales, et notamment sur des compositions et des méthodes de traitement de pathologies neuronales impliquant une dégénération axonale. Les compositions comprennent des ?-cétomides peptidiques éventuellement en combinaison avec un second agent thérapeutique. En variante, l'invention porte sur des compositions et sur des méthodes de traitement des maladies hyperprolifératives. Ce sont, par exemple, des compositions comprenant un agent antiprolifératif tel que le paclitaxel, en combinaison avec un inhibiteur de calpain tel que AK295.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)