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1. (WO2004027047) INHIBITORS OF 11&bgr;-HYDROXYSTEROID DEHYDROGENASE AND USES THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/027047    International Application No.:    PCT/US2003/030017
Publication Date: 01.04.2004 International Filing Date: 18.09.2003
IPC:
A61K 31/045 (2006.01), A61K 31/122 (2006.01), A61K 31/366 (2006.01), A61K 31/382 (2006.01), A61K 31/445 (2006.01)
Applicants: HANAUSKE-ABEL, HARTMUT M. [DE/US]; (US)
Inventors: HANAUSKE-ABEL, HARTMUT M.; (US)
Agent: GOLDMAN, Michael, L.; Nixon Peabody LLP, Clinton Square, P.O. Box 31051, Rochester, NY 14603-1051 (US)
Priority Data:
60/411,622 18.09.2002 US
Title (EN) INHIBITORS OF 11&bgr;-HYDROXYSTEROID DEHYDROGENASE AND USES THEREFOR
(FR) INHIBITEURS DE 11$G(B)-HYDROXYSTEROIDE DEHYDROGENASE ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention identifies natural and man-made inhibitors of the 11 ß-hydroxysteroid dehydrogenase enzymes that modulate glucocorticoid bioactivity in vivo by catalyzing either the formation of cortisol by reduction of cortisone, or the removal of cortisol by oxidation to cortisone. This mode of modulating glucocorticoid bioactivity in vivo is significant for inflammatory and allergic conditions, cancer, and several metabolic syndromes.
(FR)L'invention concerne l'identification d'inhibiteurs naturels et artificiels des enzymes 11ß-hydroxystéroïde déhydrogénase, lesquels modulent la bioactivité glucocorticoïde in vivo en catalysant la formation de cortisole par réduction de cortisone ou l'élimination de cortisole par oxydation en cortisone. Cette façon de moduler la bioactivité glucocorticoïde in vivo est d'importance pour les états inflammatoires et les allergies, le cancer et différents syndromes métaboliques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)