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Machine translation
1. (WO2004027037) RECOVERY OF RECOMBINANT HUMAN PARAINFLUENZA VIRUS TYPE 2 (HPIV2) FROM cDNA AND USE OF RECOMBINANT HPIV2 IN IMMUNOGENIC COMPOSITIONS AND AS VECTORS TO ELICIT IMMUNE RESPONSES AGAINST PIV AND OTHER HUMAN PATHOGENS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/027037    International Application No.:    PCT/US2003/029685
Publication Date: 01.04.2004 International Filing Date: 18.09.2003
IPC:
A61K 39/00 (2006.01), A61K 39/155 (2006.01), C07K 14/115 (2006.01), C07K 14/135 (2006.01), C12N 7/04 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; 6011 Executive Boulevard, Suite 325, Rockville, MD 20852-3804 (US) (For All Designated States Except US).
SKIADOPOULOS, Mario, H. [US/US]; (US) (For US Only).
MURPHY, Brian, R. [US/US]; (US) (For US Only).
COLLINS, Peter, L. [US/US]; (US) (For US Only)
Inventors: SKIADOPOULOS, Mario, H.; (US).
MURPHY, Brian, R.; (US).
COLLINS, Peter, L.; (US)
Agent: KING, Jeffrey, J.; Graybeal Jackson Haley LLP, 155 - 108th Avenue N.E., Suite 350, Bellevue, WA 98004 (US)
Priority Data:
60/412,053 18.09.2002 US
Title (EN) RECOVERY OF RECOMBINANT HUMAN PARAINFLUENZA VIRUS TYPE 2 (HPIV2) FROM cDNA AND USE OF RECOMBINANT HPIV2 IN IMMUNOGENIC COMPOSITIONS AND AS VECTORS TO ELICIT IMMUNE RESPONSES AGAINST PIV AND OTHER HUMAN PATHOGENS
(FR) RECUPERATION DU VIRUS PARAINFLUENZA HUMAIN DE TYPE 2 (HPIV2) RECOMBINE A PARTIR D'ADNC ET UTILISATION DE CE VIRUS HPIV2 RECOMBINE DANS DES COMPOSITIONS IMMUNOGENES ET EN TANT QUE VECTEURS POUR INDUIRE DES REPONSES IMMUNITAIRES CONTRE LE VIRUS PARAINFLUENZA ET D'AUTRES PATHOGENES HUMAINS
Abstract: front page image
(EN)Recombinant human parainfluenza virus type 2 (HPIV2) viruses and related immunogenic compositions and methods are provided. The recombinant HPIV2 viruses, including HPIV2 chimeric and chimeric vector viruses, provided according to the invention are infectious and attenuated in permissive mammalian subjects, including humans, and are useful in immunogenic compositions for eliciting an immune responses against one or more PIVs, against one or more non-PIV pathogens, or against a PIV and a non-PIV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant HPIV2 genome or antigenome.
(FR)L'invention concerne des virus parainfluenza humains de type 2 (HPIV2) recombinés, ainsi que des compositions et des procédés immunogènes apparentés. Les virus HPIV2 recombinés, incluant des virus chimériques et des virus vecteurs chimériques HPIV2, fournis selon l'invention sont infectieux et atténués chez des sujets mammifères réceptifs, notamment chez l'homme, et servent dans des compositions immunogènes pour induire une réponse immunitaire contre un ou plusieurs virus parainfluenza (PIV), contre un ou plusieurs pathogènes non PIV ou bien contre un virus PIV et un pathogène non PIV. L'invention concerne également des molécules et des vecteurs polynucléotidiques isolés contenant un génome ou un antigénome du virus HPIV2 recombiné.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)