WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2004026909) METHOD OF TREATING RHEUMATOID ARTHRITIS BY INTERFERING WITH EXPRESSION OF DC-SIGN BY MACROPHAGES AND DIAGNOSIS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/026909    International Application No.:    PCT/IB2003/005181
Publication Date: 01.04.2004 International Filing Date: 19.09.2003
IPC:
A61K 31/7004 (2006.01), A61K 38/16 (2006.01), C07K 16/28 (2006.01), G01N 33/564 (2006.01)
Applicants: STICHTING KATHOLIEKE UNIVERSITEIT [NL/NL]; Geert Grooteplein 10, P.O. Box 9101, NL-6500 HB Nijmegen (NL) (For All Designated States Except US).
FIGDOR, Carl, Gustav [NL/NL]; (NL) (For US Only).
TORENSMA, Ruurd [NL/NL]; (NL) (For US Only).
VAN LENT, Petrus, Leonardus, Everardus, Maria [NL/NL]; (NL) (For US Only).
VAN DEN BERG, Wim, B. [NL/NL]; (NL) (For US Only)
Inventors: FIGDOR, Carl, Gustav; (NL).
TORENSMA, Ruurd; (NL).
VAN LENT, Petrus, Leonardus, Everardus, Maria; (NL).
VAN DEN BERG, Wim, B.; (NL)
Agent: SOAMES, Candida, Jane; D Young & Co, 21 New Fetter Lane, London EC4A 1DA (GB)
Priority Data:
60/412,624 20.09.2002 US
Title (EN) METHOD OF TREATING RHEUMATOID ARTHRITIS BY INTERFERING WITH EXPRESSION OF DC-SIGN BY MACROPHAGES AND DIAGNOSIS THEREOF
(FR) EXPRESSION DE LA DC-SIGN PAR LES MACROPHAGES ET PROCEDES DE TRAITEMENT ET DE DIAGNOSTIC DE L'ARTHRITE RHUMATOIDE
Abstract: front page image
(EN)The C-type lectin DC-SIGN is absent in normal synovium but is highly expressed by CD68 positive macrophages in the synovium of rheumatoid arthritis patients. Accordingly, rheumatoid arthritis is diagnosed or treated by, respectively, assaying or blocking DC-SIGN. This can be accomplished by the use of agents, e.g., antibodies, which bind specifically to DCSIGN. Agents that bind to ICAM-3 are used to block inhibition of activation of macrophages by DC-SIGN-ICAM-3 interaction and cause inhibition of rheumatoid arthritis symptoms.
(FR)La lectine de type C DC-SIGN est absente de la synoviale normale, alors qu'elle est hautement exprimée par les macrophages CD68-positifs dans la synoviale des patients souffrant d'arthrite rhumatoïde. On peut, par conséquent, diagnostiquer ou traiter l'arthrite rhumatoïde en, respectivement, analysant ou bloquant la DC-SIGN, ce qui peut s'accomplir au moyen d'agents, par exemple d'anticorps, se liant spécifiquement à la DC-SIGN. On utilise des agents qui se lient à l'ICAM-3 pour bloquer l'inhibition de l'activation des macrophages par l'interaction entre la DC-SIGN et l'ICAM-3 et entraîner l'inhibition des symptômes de l'arthrite rhumatoïde.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)