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1. (WO2004026859) NOVEL IMIDAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/026859    International Application No.:    PCT/IB2003/003833
Publication Date: 01.04.2004 International Filing Date: 08.09.2003
Chapter 2 Demand Filed:    06.10.2003    
IPC:
C07D 401/14 (2006.01), C07D 405/14 (2006.01), C07D 417/14 (2006.01), C07D 471/04 (2006.01)
Applicants: PFIZER PRODUCTS INC. [US/US]; Eastern Point Road, Groton, CT 06340 (US) (For All Designated States Except US).
BLUMBERG, Laura, Cook [US/US]; (US) (For US Only).
MUNCHHOF, Michael, John [US/US]; (US) (For US Only)
Inventors: BLUMBERG, Laura, Cook; (US).
MUNCHHOF, Michael, John; (US)
Agent: LUMB, J., Trevor; Pfizer Inc., 201 Tabor Road, Morris Plains, NJ 07950 (US)
Priority Data:
60/411,894 18.09.2002 US
60/484,522 02.07.2003 US
Title (EN) NOVEL IMIDAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS
(FR) COMPOSES D'IMIDAZOLE UTILISES EN TANT QU'INHIBITEURS DU FACTEUR DE CROISSANCE TRANSFORMANT (TGF)
Abstract: front page image
(EN)Novel imidazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ('TGF')-ß signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
(FR)L'invention concerne des composés d'imidazole, des dérivés de ceux-ci, des intermédiaires destinés à leur préparation, des compositions pharmaceutiques contenant ces composés et leur utilisation thérapeutique. Ces composés consistent en des inhibiteurs puissants de la voie de passage de signalisation du facteur de croissance transformant (« TGF »)-$g(b). Ces composés sont utiles dans le traitement de divers états pathologiques, notamment, par exemple, les maladies fibrotiques et le cancer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)