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1. (WO2004026855) METHOD FOR MANUFACTURE OF DIHYDROISOBENZOFURAN DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/026855    International Application No.:    PCT/DK2003/000599
Publication Date: 01.04.2004 International Filing Date: 17.09.2003
IPC:
C07D 491/10 (2006.01)
Applicants: H. LUNDBECK A/S [DK/DK]; 9 Ottiliavej, DK-2500 Valby, Copenhagen (DK) (For All Designated States Except US).
SOMMER, Michael, Bech [DK/DK]; (DK) (For US Only).
NIELSEN, Ole [DK/DK]; (DK) (For US Only)
Inventors: SOMMER, Michael, Bech; (DK).
NIELSEN, Ole; (DK)
Priority Data:
PA 2002 01390 20.09.2002 DK
Title (EN) METHOD FOR MANUFACTURE OF DIHYDROISOBENZOFURAN DERIVATIVES
(FR) PROCEDE DE PREPARATION DE DERIVES DE DIHYDROISOBENZOFURANNE
Abstract: front page image
(EN)The present invention relates to a method for the manufacture of dihydroisobenzofurans of formula I; comprising generation a dianion of formula II, reaction of the dianion with a carbonyl compound of formula III and acidification of the reaction mixture to generate a diol of formula IV; followed by ring closure of the diol of formula IV to obtain the dihydroisobenzofuran of formula I.
(FR)La présente invention concerne un procédé de préparation de dihydroisobenzofurannes de formule (I). Ce procédé consiste à produire un dianion de formule (II), à faire réagir ce dianion avec un composé carbonyle de formule (III) et à acidifier le mélange de réaction en vue de produire un diol de formule (IV), puis à opérer la cyclisation du diol de formule (IV) de sorte à obtenir le dihydroisobenzofuranne de formule (I).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)