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1. WO2004024723 - ANTIDEPRESSANT CYCLOALKYLAMINE DERIVATIVES OF 2,3-DIHYDRO-1,4-BENZODIOXAN

Publication Number WO/2004/024723
Publication Date 25.03.2004
International Application No. PCT/US2003/028296
International Filing Date 11.09.2003
Chapter 2 Demand Filed 02.04.2004
IPC
C07D 405/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61P 1/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
A61P 15/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
08for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
A61P 15/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
10for impotence
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P 25/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
A61P 25/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
Applicants
  • WYETH [US]/[US] (AllExceptUS)
  • EVRARD, Deborah, Ann [US]/[US] (UsOnly)
  • SHAH, Uresh, Shantilal [US]/[US] (UsOnly)
  • STACK, Gary, Paul [US]/[US] (UsOnly)
Inventors
  • EVRARD, Deborah, Ann
  • SHAH, Uresh, Shantilal
  • STACK, Gary, Paul
Agents
  • LUCCI, Joseph
Priority Data
10/659,19310.09.2003US
60/410,16912.09.2002US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIDEPRESSANT CYCLOALKYLAMINE DERIVATIVES OF 2,3-DIHYDRO-1,4-BENZODIOXAN
(FR) DERIVES CYCLOALKYLAMINE DE 2,3-DIHYDRO-1,4-BENZODIOXANE ANTIDEPRESSEURS
Abstract
(EN)
Compounds of the formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
(FR)
L'invention concerne des composés de formule I, utiles pour le traitement de la dépression (entre autres, troubles dépressifs majeurs, dépression infantile et dysthymie), anxiété, panique, stress post-traumatique, trouble dysphorique prémenstruel (encore appelé syndrome prémenstruel), trouble déficitaire de l'attention (avec et sans hyperactivité), trouble obsessivo-compulsif, angoisse sociale, anxiété généralisée, obésité, troubles de l'alimentation comme l'anorexie mentale et la boulimie, bouffées vasomotrices, cocaïnomanie et alcoolisme, dysfonctionnement sexuel et maladies connexes.
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