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1. (WO2004024160) COMBINATION OF A) N-{5-[4-(4-METHYL-PIPERAZINO-METHYL)-BENZOYLAMIDO]-2-METHYLPHENYL}-4-(3-PYRIDYL)-2-PYRIMIDINE-AMINE AND B) A HISTONE DEACETYLASE INHIBITOR FOR THE TREATMENT OF LEUKEMIA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2004/024160 International Application No.: PCT/IB2003/004053
Publication Date: 25.03.2004 International Filing Date: 10.09.2003
Chapter 2 Demand Filed: 27.03.2004
IPC:
A61K 31/165 (2006.01) ,A61K 31/166 (2006.01) ,A61K 31/19 (2006.01) ,A61K 31/404 (2006.01) ,A61K 31/4406 (2006.01) ,A61K 31/506 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
166
having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4406
only substituted in position 3, e.g. zimeldine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
Applicants:
VIRGINIA COMMONWEALTH UNIVERSITY [US/US]; 1101 East Marshall Street Richmond, VA 23298-0568, US (AllExceptUS)
MCGUIRE VA MEDICAL CENTER 111K [US/US]; 1201 Broad Rock Boulevard Richmond, VA 23249, US (AllExceptUS)
DENT, Paul [US/US]; US (UsOnly)
GRANT, Steven [US/US]; US (UsOnly)
KRYSTAL, Geoffrey [US/US]; US (UsOnly)
YU, Chunrong [CN/US]; US (UsOnly)
Inventors:
DENT, Paul; US
GRANT, Steven; US
KRYSTAL, Geoffrey; US
YU, Chunrong; US
Agent:
HOXIE, Thomas; Novartis AG Corporate Intellectual Property CH-4002 Basel, CH
Priority Data:
60/410,28613.09.2002US
60/411,34418.09.2002US
Title (EN) COMBINATION OF A) N-{5-[4-(4-METHYL-PIPERAZINO-METHYL)-BENZOYLAMIDO]-2-METHYLPHENYL}-4-(3-PYRIDYL)-2-PYRIMIDINE-AMINE AND B) A HISTONE DEACETYLASE INHIBITOR FOR THE TREATMENT OF LEUKEMIA
(FR) COMBINAISON DE A) N-{5-[4-(4-METHYL-PIPERAZINO-METHYL)-BENZOYLAMIDO]-2-METHYLPHENYL}-4-(3-PYRIDYL)-2-PYRIMIDINE-AMINE ET B) D'UN INHIBITEUR DE L'HISTONE DEACETYLASE POUR LE TRAITEMENT DE LA LEUCEMIE
Abstract:
(EN) The invention pertains to a combination of a histone deacetylase inhibitor and N-[5-[4-(4methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine or a pharmaceutically acceptable salt thereof for simultaneous, separate or sequential use for the treatment of leukemia and especially N-15-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2methylphenyl)-4-(3-pyridyl)-2-pyrimidine-resistant leukemia.
(FR) L'invention concerne une combinaison d'un inhibiteur de l'histone déacétylase et de N-[5-[4-(4méthyl-pipérazino-méthyl)-benzoylamido]-2-méthylphényl}-4-(3-pyridyl)-2-pyrimidine ou d'un sel pharmaceutiquement acceptable de ce dernier en vue de son utilisation simultanée, séparée ou ou séquentielle dans le traitement de la leucémie, en particulier la leucémie résistant à N-[5-[4-(4méthyl-pipérazino-méthyl)-benzoylamido]-2-méthylphényl}-4-(3-pyridyl)-2-pyrimidine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LT, LU, LV, MA, MD, MK, MN, MX, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SE, SG, SK, SY, TJ, TM, TN, TR, TT, UA, US, UZ, VC, VN, YU, ZA, ZW
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1553948JP2006501267US20060100140CN1681505CA2498210AU2003259521