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1. WO2004021008 - METHODS FOR DETECTING BREAST AND OVARIAN CANCER

Publication Number WO/2004/021008
Publication Date 11.03.2004
International Application No. PCT/CA2003/001310
International Filing Date 28.08.2003
IPC
G01N 33/574 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
CPC
C12Q 1/37
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
34involving hydrolase
37involving peptidase or proteinase
G01N 2333/96455
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
90Enzymes; Proenzymes
914Hydrolases (3)
948acting on peptide bonds (3.4)
95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
964derived from animal tissue
96425from mammals
96427in general
9643with EC number
96433Serine endopeptidases (3.4.21)
96441with definite EC number
96455Kallikrein (3.4.21.34; 3.4.21.35)
G01N 2500/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
G01N 33/57415
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57407Specifically defined cancers
57415of breast
G01N 33/57449
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57407Specifically defined cancers
57449of ovaries
G01N 33/57484
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57484involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
Applicants
  • MOUNT SINAI HOSPITAL [CA]/[CA] (AllExceptUS)
  • YOUSEF, George [EG]/[CA] (UsOnly)
  • DIAMANDIS, Eleftherios, P. [CA]/[CA] (UsOnly)
Inventors
  • YOUSEF, George
  • DIAMANDIS, Eleftherios, P.
Agents
  • KURDYDYK, Linda
Priority Data
60/407,33328.08.2002US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR DETECTING BREAST AND OVARIAN CANCER
(FR) METHODES DE DETECTION DU CANCER DU SEIN ET DES OVAIRES
Abstract
(EN)
Kallikrein 5 constitutes a novel biomarker for diagnosis, treatment and monitoring of breast and ovarian cancer. A method is provided for diagnosing and monitoring breast or ovarian cancer or a predisposition to breast or ovarian cancer, in a subject comprising detecting kallikrein 5 in a sample from the subject. Imaging methods, screening methods for test agents for inhibiting breast or ovarian cancer, and therapeutic applications based on kallikrein 5 are also described.
(FR)
Selon cette invention, la kallicréine 5 constitue un nouveau biomarqueur destiné au diagnostic, au traitement et à la surveillance du cancer du sein et des ovaires. Ladite invention concerne une méthode destinée à diagnostiquer et surveiller un cancer du sein ou des ovaires ou une prédisposition au cancer du sein ou des ovaires chez un sujet, cette méthode consistant à détecter la kallicréine 5 dans un échantillon provenant du sujet. L'invention a aussi pour objet des méthodes d'imagerie, des méthodes de criblage d'agents d'essai élaborées pour inhiber le cancer du sein ou des ovaires, et des applications thérapeutiques reposant sur la kallicréine 5.
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