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1. WO2004020289 - PROCESS FOR PRODUCING METERED DOSE INHALER FORMULATIONS

Publication Number WO/2004/020289
Publication Date 11.03.2004
International Application No. PCT/US2003/026512
International Filing Date 26.08.2003
Chapter 2 Demand Filed 12.03.2004
IPC
B65B 31/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
31Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
CPC
A61M 11/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
11Sprayers or atomisers specially adapted for therapeutic purposes
04operated by the vapour pressure of the liquid to be sprayed or atomised
A61M 15/0065
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
15Inhalators
0065Inhalators with dosage or measuring devices
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
B65B 3/003
BPERFORMING OPERATIONS; TRANSPORTING
65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
3Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
003Filling medical containers such as ampoules, vials, syringes or the like
B65B 31/003
BPERFORMING OPERATIONS; TRANSPORTING
65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
31Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
003Adding propellants in fluid form to aerosol containers
Applicants
  • SCHERING CORPORATION [US]/[US] (AllExceptUS)
  • CHAUDHRY, Saeed [US]/[US] (UsOnly)
  • SHARPE, Stefan, A. [US]/[US] (UsOnly)
  • BERRY, Julianne [US]/[US] (UsOnly)
  • SEQUEIRA, Joel, A. [US]/[US] (UsOnly)
Inventors
  • CHAUDHRY, Saeed
  • SHARPE, Stefan, A.
  • BERRY, Julianne
  • SEQUEIRA, Joel, A.
Agents
  • LIPKA, Robert, J.
Priority Data
60/406,12727.08.2002US
60/422,43630.10.2002US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PRODUCING METERED DOSE INHALER FORMULATIONS
(FR) PROCEDE DE PRODUCTION DE PREPARATIONS POUR AEROSOLS-DOSEURS
Abstract
(EN)
Disclosed are methods of introducing a suspension or solution of a medicament, preferably mometasone furoate anhydrous, into a metered dose inhaler container, said container having a valve attached thereto, said method comprising the steps of introducing mometasone furoate anhydrous, a surfactant and a chlorflourocarbon free propellant into a vessel that is held under pressure to form a suspension or solution, circulating said suspension or solution from the vessel through a line which includes a filling head, bringing said filling head into communication with said metered dose inhaler container through said valve of said metered dose inhaler container, introducing a quantity of such suspension or solution into the container from the filling head of the line through said valve of said metered dose inhaler container, withdrawing said filling head from said metered dose inhaler container, and sealing said metered dose inhaler container, as well as the products produced thereby having an improved particle size distribution of the active ingredients in metered dose inhalers.
(FR)
La présente invention concerne des procédés d'introduction d'une suspension ou d'une solution de médicament, de préférence de furoate de mométasone anhydreux, dans un aérosol-doseur, ledit aérosol présentant une valve, ledit procédé consistant à introduire du furoate de mométasone anhydreux, un tensio-actif ainsi qu'un gaz propulseur dépourvu de chlorofluorocarbure dans un récipient qui est maintenu sous pression afin de former une suspension ou une solution, à faire circuler ladite suspension ou solution à partir dudit récipient dans un conduit qui comprend une tête de remplissage, à amener ladite tête de remplissage en communication avec ledit aérosol-doseur par l'intermédiaire de ladite valve dudit aérosol-doseur, à introduire une quantité de ladite suspension ou solution dans l'aérosol à partir de la tête de remplissage du conduit par l'intermédiaire de ladite valve dudit aérosol-doseur, à retirer ladite tête de remplissage dudit aérosol-doseur et à fermer de manière étanche ledit aérosol-doseur. L'invention concerne également des produits obtenus selon lesdits procédés et présentant une distribution granulométrique améliorée des principes actifs dans des aérosols-doseurs.
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