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1. WO2004019989 - INCLUSION COMPOUND OF NATEGLINIDE

Publication Number WO/2004/019989
Publication Date 11.03.2004
International Application No. PCT/CN2003/000707
International Filing Date 22.08.2003
Chapter 2 Demand Filed 08.03.2004
IPC
A61K 31/198 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
CPC
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61K 47/6951
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6949inclusion complexes, e.g. clathrates, cavitates or fullerenes
6951using cyclodextrin
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
B82Y 5/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Applicants
  • ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. [CN]/[CN] (AllExceptUS)
  • NIU, Zhanqi [CN]/[CN] (UsOnly)
  • WANG, Lifang [CN]/[CN] (UsOnly)
  • CHEN, Yujie [CN]/[CN] (UsOnly)
  • SHEN, Dongmin [CN]/[CN] (UsOnly)
Inventors
  • NIU, Zhanqi
  • WANG, Lifang
  • CHEN, Yujie
  • SHEN, Dongmin
Agents
  • NTD PATENT & TRADEMARK AGENCY LIMITED BEIJING OFFICE
Priority Data
02132321.627.08.2002CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) INCLUSION COMPOUND OF NATEGLINIDE
(FR) COMPOSE D'INCLUSION A BASE DE NATEGLINIDE
Abstract
(EN)
The invention relates to a inclusion compound of nateglinide, containing nateglinide as active component and ß -cyclodextrin and its derivates, particularly to a nateglinide - ß -cyclodextrin inclusion compound. Its preparing process comprises the saturated solution methold, ultrasonic methold and grinding methold. The inclusion compound has high stability, and can be used as a starting material or component in the manufacture of pharmaceutical formulation.
(FR)
L'invention se rapporte à un composé d'inclusion à base de natéglinide, qui contient du natéglinide en tant que principe actif et une $g(b)-cyclodextrine, ainsi qu'à ses dérivés, notamment à un composé d'inclusion du type natéglinide/$g(b)-cyclodextrine. Le processus de préparation de ce composé fait appel à un procédé mis en oeuvre en solution saturée, à un procédé ultrasonore et à un procédé de broyage. Le composé d'inclusion de l'invention présente une grande stabilité et il peut être utilisé en tant que matière première ou en tant que composant de départ pour la fabrication d'une formulation pharmaceutique.
Also published as
Latest bibliographic data on file with the International Bureau