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1. WO2004018521 - ANTI-IDIOTYPE ANTIBODY, METHOD OF CONSTRUCTING THE ANTI-IDIOTYPE ANTIBODY AND METHOD OF PREPARING IDIOTYPE ANTIBODY USING THE ANTI-IDIOTYPE ANTIBODY

Publication Number WO/2004/018521
Publication Date 04.03.2004
International Application No. PCT/JP2003/010671
International Filing Date 22.08.2003
Chapter 2 Demand Filed 11.03.2004
IPC
C07K 16/42 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
42against immunoglobulins (anti-idiotypic antibodies)
CPC
C07K 16/4208
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
42against immunoglobulins
4208against an idiotypic determinant on Ig
Applicants
  • PEPTIDE DOOR CO.,LTD. [JP]/[JP] (AllExceptUS)
  • SUZUKI, Masatsugu [JP]/[JP] (UsOnly)
Inventors
  • SUZUKI, Masatsugu
Agents
  • MATSUI, Shigeru
Priority Data
2002-24169522.08.2002JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ANTI-IDIOTYPE ANTIBODY, METHOD OF CONSTRUCTING THE ANTI-IDIOTYPE ANTIBODY AND METHOD OF PREPARING IDIOTYPE ANTIBODY USING THE ANTI-IDIOTYPE ANTIBODY
(FR) ANTICORPS ANTI-IDIOTYPE, PROCEDE DE CONSTRUCTION DE CET ANTICORPS ANTI-IDOTYPE ET PROCEDE DE PREPARATION D'ANTICORPS IDIOTYPE FAISANT APPEL AUDIT ANTICORPS ANTI-IDOTYPE
(JA) 抗イディオタイプ抗体、該抗イディオタイプ抗体の作成方法、及び該抗イディオタイプ抗体を用いたイディオタイプ抗体の調製方法
Abstract
(EN)
It is intended to provide an anti-idiotype antibody which can be conveniently and economically constructed compared with the existing type; a method of constructing the anti-idiotype antibody; and a method of preparing a target idiotype antibody using the above-described anti-idiotype antibody. A substance binding to the antigen-binding site of a first antibody is prepared and this substance is ligated to a second antigen to give a fused antigen. Next, this fused antigen is bonded to a second antibody capable of binding to the second antigen as described above, thereby giving an anti-idiotype antibody against the first antibody. In a method of preparing a specific idiotype antibody which comprises inoculating an animal with an anti-idiotype antibody to the idiotype antibody and then further inoculating with an antigen of the above idiotype antibody, the anti-idiotype antibody as described above is employed. Thus, the target idiotype antibody can be efficiently obtained.
(FR)
L'invention concerne un anticorps anti-idiotype qui peut être construit de façon pratique et économique si l'on compare avec le type existant, un procédé de construction de cet anticorps anti-idiotype et un procédé de préparation d'un anticorps idiotype cible faisant appel audit anticorps anti-idiotype. Selon l'invention, on prépare une substance se fixant au site de liaison à l'antigène d'un premier anticorps, cette substance étant ensuite liée à un second antigène pour donner un antigène fusionné. Ensuite, on fixe ledit antigène fusionné à un second anticorps pouvant se fixer audit second antigène, ce qui permet d'obtenir un anticorps anti-idiotype dirigé contre le premier anticorps. On utilise ledit anticorps anti-idiotype dans un procédé de préparation d'un anticorps idiotype spécifique qui consiste à inoculer à un animal un anticorps anti-idiotype dirigé contre l'anticorps idiotype, puis à également inoculer à l'animal un antigène dudit anticorps idiotype. On obtient ainsi de façon efficace l'anticorps idiotype cible.
(JA)
 本発明は、従来の方法に比べて簡単且つ安価に作成することのできる抗イディオタイプ抗体、その作成方法、及び該抗イディオタイプ抗体を用いた目的とするイディオタイプ抗体の調製方法を提供する。 第1抗体の抗原結合部位に結合する物質を調製し、該物質を第2抗原に連結して融合抗原を作成し、この融合抗原と前記第2抗原に結合する第2抗体とを結合させることにより、前記第1抗体に対する抗イディオタイプ抗体を得る。また、動物に、特定のイディオタイプ抗体に対する抗イディオタイプ抗体を接種した後、前記イディオタイプ抗体の抗原を接種することにより、前記イディオタイプ抗体を調製する方法において、本発明の抗イディオタイプ抗体を用いることにより、効率よく目的とするイディオタイプ抗体を得ることができる。
Also published as
US2006247424
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