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1. WO2004017988 - ENZYME CONTAINING COMPOSITION, PROCESS OF PRODUCING SAID COMPOSITION AND ITS USE

Publication Number WO/2004/017988
Publication Date 04.03.2004
International Application No. PCT/EP2003/005183
International Filing Date 16.05.2003
Chapter 2 Demand Filed 09.02.2004
IPC
A61K 38/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
CPC
A61K 38/47
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
47acting on glycosyl compounds (3.2), e.g. cellulases, lactases
A61K 38/482
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
482Serine endopeptidases (3.4.21)
A61K 38/488
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
488Aspartic endopeptidases (3.4.23), e.g. pepsin, chymosin, renin, cathepsin E
A61K 38/4886
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
4886Metalloendopeptidases (3.4.24), e.g. collagenase
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
Applicants
  • 3M ESPE AG [DE]/[DE] (AllExceptUS)
  • HÄBERLEIN, Ingo [DE]/[DE] (UsOnly)
  • GUGGENBERGER, Rainer [DE]/[DE] (UsOnly)
  • WEINMANN, Wolfgang [DE]/[DE] (UsOnly)
  • KAPPLER, Oliver [DE]/[DE] (UsOnly)
Inventors
  • HÄBERLEIN, Ingo
  • GUGGENBERGER, Rainer
  • WEINMANN, Wolfgang
  • KAPPLER, Oliver
Agents
  • FIESSER, Gerold
Priority Data
102 37 317.515.08.2002DE
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ENZYME CONTAINING COMPOSITION, PROCESS OF PRODUCING SAID COMPOSITION AND ITS USE
(FR) COMPOSITION CONTENANT DES ENZYMES, PROCEDE DE PRODUCTION DE ET UTILISATION DE CETTE COMPOSITION
Abstract
(EN)
The present invention relates to a composition comprising at least one biologically active protease and at least one biologically active glycosidase wherein the proteases and the glycosidases are present in an activity ratio of from 1,000,000 : 1 to 1 : 1,000,000 and wherein the composition has a total enzyme activity of at least 2 U / ml. Furthermore, the present invention relates to a process of producing such an enzyme comprising composition and to processes of removing caries. Moreover, the invention relates to the use of one or more enzyme comprising compositions for producing a treatment agent for removing caries.
(FR)
La présente invention concerne une composition comprenant au moins une protéase biologiquement active et au moins une glycosidase biologiquement active, lesquelles protéases et glycosidases sont présentes dans la composition selon un rapport des activités compris entre 1 000 000:1 et 1:1 000 000. Cette composition présente une activité enzymatique totale d'au moins 2 U/ml. Cette invention concerne en outre un procédé de production de cette composition contenant des enzymes ainsi que des procédés permettant d'éliminer les caries. Cette invention porte par ailleurs sur l'utilisation d'une ou plusieurs compositions contenant des enzymes pour produire un agent thérapeutique servant à éliminer les caries.
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