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Machine translation
1. (WO2004009836) PR/SET-DOMAIN CONTAINING NUCLEIC ACIDS, POLYPEPTIDES, ANTIBODIES AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/009836    International Application No.:    PCT/US2003/022509
Publication Date: 29.01.2004 International Filing Date: 18.07.2003
IPC:
C12N 15/00 (2006.01), C12N 5/10 (2006.01), C12N 1/21 (2006.01), C07H 21/00 (2006.01), C12Q 1/68 (2006.01), C12P 21/06 (2006.01), C07K 14/00 (2006.01), C12N 9/00 (2006.01)
Applicants: THE BURNHAM INSTITUTE [US/US]; 10901 North Torrey Pines Road, La Jolla, CA 92037 (US) (For All Designated States Except US).
HUANG, Shi [CN/US]; (US) (For US Only)
Inventors: HUANG, Shi; (US)
Agent: GUY, Pamela, M.; McDermott, Will & Emery, 4370 La Jolla Village Drive, 7th Floor, San Diego, CA 92122 (US)
Priority Data:
10/200,012 18.07.2002 US
Title (EN) PR/SET-DOMAIN CONTAINING NUCLEIC ACIDS, POLYPEPTIDES, ANTIBODIES AND METHODS OF USE
(FR) DOMAINE PR/SET CONTENANT DES ACIDES NUCLEIQUES, DES POLYPEPTIDES, DES ANTICORPS ET PROCEDES D'UTILISATION CORRESPONDANT
Abstract: front page image
(EN)The present invention provides an isolated nucleic acid molecule encoding a PFM/SET polypeptide. Also provided is an isolated nucleic acid molecule encoding a functional fragment of a PFM/SET polypeptide that contains a SET domain of a PFM/SET polypeptide of the invention. Further provided by the invention are PFM/SET polypeptides, and functional fragments thereof that contain a SET domain of a PFM/SET polypeptide. The invention also provides PFM/SET antibodies, PFM/SET modulatory compounds, and related methods. The molecules of the invention can be used in methods of screening for a compound that modulates PFM/SET polypeptide histone methyltransferase activity and to modulate cell proliferation to prevent or treat proliferative disorders, including cancer. Additionally, the molecules and methods of the invention can be used to diagnose and prognose proliferative disorders.
(FR)L'invention concerne une molécule d'acide nucléique isolée codant un polypeptide PFM/SET. L'invention concerne également une molécule d'acide nucléique isolée codant un fragment fonctionnel d'un polypeptide PFM/SET contenant un domaine SET d'un polypeptide PFM/SET de l'invention. En outre, l'invention concerne des polypeptides PFM/SET, et des fragments fonctionnels de ceux-ci qui contiennent un domaine SET d'un polypeptide PFM/SET. L'invention concerne également des anticorps PFM/SET, des composés modulateurs, et des procédés associés. Les molécules de l'invention peuvent être utilisées dans des procédés de criblage pour un composé modulant l'activité méthyltransférase histone du polypeptide PFM/SET et en vue de moduler la prolifération de cellules afin de prévenir ou traiter des troubles prolifératifs, notamment le cancer. Enfin, les molécules et les procédés de l'invention peuvent être utilisés dans le diagnostic et le pronostic de troubles prolifératifs.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)