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Machine translation
1. (WO2004009789) TARGETED ADENOVIRAL VECTOR DISPLAYING IMMUNOGLOBULIN-BINDING DOMAIN AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/009789    International Application No.:    PCT/US2003/022966
Publication Date: 29.01.2004 International Filing Date: 22.07.2003
IPC:
C07K 16/00 (2006.01), C07K 16/28 (2006.01), C12N 15/861 (2006.01)
Applicants: VECTORLOGICS, INC. [US/US]; 824 Linwood Road, Birmingham, AL 35222 (US).
EMD LEXIGEN RESEARCH CENTER [US/US]; 45A Middlesex Turnpike, Billerica, MA 01821-3936 (US)
Inventors: KOROKHOV, Nikolay; (US).
MIKHEEVA, Galina; (US)
Agent: KOWALSKI, Thomas, J.; Frommer Lawrence & Haug LLP, 745 Fifth Avenue, New York, NY 10151 (US)
Priority Data:
60/398,057 22.07.2002 US
Title (EN) TARGETED ADENOVIRAL VECTOR DISPLAYING IMMUNOGLOBULIN-BINDING DOMAIN AND USES THEREOF
(FR) VECTEUR ADENOVIRAL CIBLE PRESENTANT UN DOMAINE DE FIXATION A L'IMMUNOGLOBULINE ET SES APPLICATIONS
Abstract: front page image
(EN)The present invention provides a targeted recombinant adenovirus vector expressing a fiber protein modified by insertion of an immunoglobulin-binding domain that can crosslink to a fusion protein comprising a targeting ligand and an immunoglobulin Fc domain. Interaction between the immunoglobulin-binding domain and the Fc domain results in a targeted vector::ligand complex, thereby targeting the adenovirus vector to a cell that expresses a cell surface molecule that binds to said targeting ligand.
(FR)La présente invention concerne un vecteur adénoviral recombiné, ciblé, exprimant une protéine fibreuse modifiée par insertion d'un domaine de fixation à l'immunoglobuline pouvant former une liaison avec une protéine de fusion comprenant un ligand-cible et un domaine Fc d'immunoglobuline. L'interaction entre le domaine de fixation à l'immunoglobuline et le domaine Fc permet d'obtenir un complexe vecteur ciblé::ligand, et ainsi de diriger le vecteur adénoviral vers une cellule qui exprime une molécule de surface qui se fixe audit ligand-cible.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)