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Machine translation
1. (WO2004009664) BIODEGRADABLE TRIBLOCK COPOLYMERS, SYNTHESIS METHODS THEREFOR, AND HYDROGELS AND BIOMATERIALS MADE THERE FROM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/009664    International Application No.:    PCT/US2003/022561
Publication Date: 29.01.2004 International Filing Date: 18.07.2003
Chapter 2 Demand Filed:    19.02.2004    
IPC:
A61K 9/00 (2006.01), A61K 9/51 (2006.01), A61K 47/32 (2006.01), A61K 47/34 (2006.01), A61K 47/48 (2006.01), A61L 27/34 (2006.01), A61L 27/52 (2006.01), A61L 27/54 (2006.01), A61L 31/10 (2006.01), A61L 31/14 (2006.01), A61L 31/16 (2006.01)
Applicants: OMEROS CORPORATION [US/US]; Suite 2600, 1420 Fifth Avenue, Seattle, WA 98101 (US) (For All Designated States Except US).
INSTITUTE OF MATERIALS RESEARCH AND ENGINEERING [SG/SG]; 3 Research Link, Singapore 117602 (SG) (For All Designated States Except US).
LI, Jun [CN/SG]; (SG) (For US Only).
LI, Xu [CN/SG]; (SG) (For US Only).
NI, Xiping [CN/SG]; (SG) (For US Only).
LEONG, Kam, W. [US/US]; (US) (For US Only)
Inventors: LI, Jun; (SG).
LI, Xu; (SG).
NI, Xiping; (SG).
LEONG, Kam, W.; (US)
Agent: KELBON, Marcia, S., Esq.; Omeros Corporation, 1420 Fifth Avenue, Suite 2600, Seattle, WA 98101 (US)
Priority Data:
60/397,129 19.07.2002 US
60/439,171 10.01.2003 US
Title (EN) BIODEGRADABLE TRIBLOCK COPOLYMERS, SYNTHESIS METHODS THEREFOR, AND HYDROGELS AND BIOMATERIALS MADE THERE FROM
(FR) COPOLYMERES TRIBLOCS BIODEGRADABLES, PROCEDES DE SYNTHESE, ET HYDROGELS ET BIOMATERIAUX FABRIQUES A PARTIR DE CES DERNIERS
Abstract: front page image
(EN)A drug delivery system that includes a hydrogel formed from cyclodextrin and an amphiphilic copolymer that includes an A polymer block comprising a poly(alkylene oxide) and a B polymer block comprising a poly(hydroxyalkanoate), and a therapeutically effective amount of at least one therapeutic agent intimately contained within the hydrogel. In one preferred embodiment of the invention, the A polymer block 10 is poly(ethylene oxide) (PEO) and the B polymer block is poly[(R)-3-hydroxybutyrate] (PHB), and the copolymer is the triblock ABA copolymer PEO-PHB-PEO. A method of synthesizing the amphiphilic triblock copolymer is also provided.
(FR)La présente invention concerne un système de délivrance de médicament qui comprend un hydrogel formé de cyclodextrine et d'un copolymère amphiphile renfermant un bloc de polymère A comprenant un oxyde de polyalkylène et un bloc de polymère B comprenant un polyhydroxyalcanoate, et une quantité thérapeutiquement efficace d'au moins un agent thérapeutique intimement contenu à l'intérieur de l'hydrogel. Dans un mode de réalisation préféré de l'invention, le bloc de polymère A est un oxyde de polyéthylène (PEO) et le bloc de polymère B est un poly[(R)-3-hydroxybutyrate] (PHB), et le copolymère est le copolymère tribloc ABA PEO-PHB-PEO. L'invention se rapporte également à un procédé de synthèse du copolymère tribloc amphiphile précité.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)