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1. WO2004009613 - ANTI-INFLAMMATORY OR ANTI-ALLERGIC ANDROSTANE COMPLEXES

Publication Number WO/2004/009613
Publication Date 29.01.2004
International Application No. PCT/EP2003/008388
International Filing Date 21.07.2003
Chapter 2 Demand Filed 26.01.2004
IPC
A61K 31/58 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
58containing heterocyclic rings, e.g. aldosterone, danazol, stanozolol, pancuronium, digitogenin
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C07J 31/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
31Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
CPC
A61K 31/58
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
58containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 37/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
C07J 17/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
17Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
Applicants
  • GLAXO GROUP LIMITED [GB]/[GB] (AllExceptUS)
  • BIGGADIKE, Keith [GB]/[GB] (UsOnly)
  • CHETINA, Olga [RU]/[GB] (UsOnly)
  • COOTE, Steven, John [GB]/[GB] (UsOnly)
  • CRAIG, Andrew, Simon [GB]/[GB] (UsOnly)
  • JACEWICZ, Victor, Witold [GB]/[GB] (UsOnly)
  • MILLAN, Michael, John [AU]/[GB] (UsOnly)
  • SEAGER, John, Frederick [GB]/[GB] (UsOnly)
  • THEOPHILUS, Andrew, Lewis [GB]/[GB] (UsOnly)
Inventors
  • BIGGADIKE, Keith
  • CHETINA, Olga
  • COOTE, Steven, John
  • CRAIG, Andrew, Simon
  • JACEWICZ, Victor, Witold
  • MILLAN, Michael, John
  • SEAGER, John, Frederick
  • THEOPHILUS, Andrew, Lewis
Agents
  • PRITCHARD, Judith
  • GIDDINGS, Peter, John
Priority Data
10/200,36422.07.2002US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-INFLAMMATORY OR ANTI-ALLERGIC ANDROSTANE COMPLEXES
(FR) COMPLEXES D'ANDROSTANE ANTI-INFLAMMATOIRES OU ANTI-ALLERGIQUES
Abstract
(EN)
There is provided a crystalline chemical complex comprising a compound of formula (I) in which the crystal lattice is stabilised by the presence of a guest molecule, characterised in that the crystalline complex is of space group P212121 having unit cell dimensions of about 7.6 ± 0.6 Å, 12.7 ± 0.7 Å, and 33 ± 3 Å when determined at 120K.
(FR)
La présente invention concerne un complexe chimique cristallin comprenant un composé de formule (I). Ledit complexe, dans lequel le réseau cristallin est stabilisé par la présence d'une molécule hôte, se caractérise en ce qu'il est constitué d'un complexe spatial P212121 présentant des dimensions des cellules élémentaires d'environ 7,6 ± 0,6 Å, 12,7 ± 0,7 Å, et 33 ± 3 Å lorsque la détermination s'effectue à 120K.
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