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1. (WO2004009582) SUBSTITUTED THIOPHENE CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/009582    International Application No.:    PCT/US2003/022768
Publication Date: 29.01.2004 International Filing Date: 18.07.2003
Chapter 2 Demand Filed:    17.02.2004    
IPC:
C07D 333/74 (2006.01), C07D 333/80 (2006.01)
Applicants: PHARMACIA CORPORATION [US/US]; 700 Chesterfield Parkway West, Chesterfield, MI 63017-1732 (US) (For All Designated States Except US).
HAGEN, Timothy, J. [US/US]; (US) (For US Only).
WEIER, Richard, M. [US/US]; (US) (For US Only).
XU, Xiangdong [CN/US]; (US) (For US Only).
HOUDEK, Stephen, C. [US/US]; (US) (For US Only).
CLARE, Michael [GB/US]; (US) (For US Only)
Inventors: HAGEN, Timothy, J.; (US).
WEIER, Richard, M.; (US).
XU, Xiangdong; (US).
HOUDEK, Stephen, C.; (US).
CLARE, Michael; (US)
Agent: BAUER, S., Christopher; Pharmacia Corporation, Corporate Patent Department, P.O. Box 1027, Chesterfield, MO 63006 (US)
Priority Data:
60/397,052 19.07.2002 US
Title (EN) SUBSTITUTED THIOPHENE CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION
(FR) COMPOSES DE THIOPHENE CARBOXAMIDE SUBSTITUES UTILISES POUR TRAITER UNE INFLAMMATION
Abstract: front page image
(EN)The present invention provides substituted thiophene carboxamide compounds having structural Formula I and isomers, tautomers, polymorphs, carriers, prodrugs, and pharmaceutically acceptable salts thereof, compositions comprising such, and methods for treating diseases associated with kinase activity. More specifically, the present invention provides methods of treatment of a variety of diseases associated with IKK2 including the treatment of inflammation, other inflammation-associated disorders, such as, as an analgesic in the treatment of pain and headaches, arthritis, including but not limited to rheumatoid arthritis, asthma, gastrointestinal conditions such as inflammatory bowel disease, vascular diseases, viral infections such as AIDS, and cancer.
(FR)La présente invention concerne des composés de thiophène carboxamide substitués de formule structurelle (I) et des isomères, tautomères, polymorphes, supports, promédicaments et sels de ceux-ci, acceptables d'un point de vue pharmaceutique, des compositions comprenant ces composés, ainsi que des procédés pour traiter des maladies associées à une activité de kinase. Cette invention concerne plus particulièrement des procédés pour traiter une variété de maladies associées à IKK2, notamment pour traiter une inflammation, d'autres troubles associés à une inflammation, par exemple en tant qu'analgésique pour traiter la douleur et les maux de tête, l'arthrite, notamment la polyarthrite rhumatoïde, l'asthme, des pathologies gastro-intestinales comme une affection abdominale inflammatoire, des maladies vasculaires, des infections virales comme le SIDA, et le cancer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)