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Machine translation
1. (WO2004009555) 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/009555    International Application No.:    PCT/JP2003/009158
Publication Date: 29.01.2004 International Filing Date: 18.07.2003
Chapter 2 Demand Filed:    18.07.2003    
IPC:
C07D 217/04 (2006.01)
Applicants: ASAHI KASEI PHARMA CORPORATION [JP/JP]; 9-1, Kanda Mitoshiro-cho, Chiyoda-ku, Tokyo 101-8481 (JP) (For All Designated States Except US).
YAMADA, Rintaro [JP/JP]; (JP) (For US Only).
SETO, Minoru [JP/JP]; (JP) (For US Only)
Inventors: YAMADA, Rintaro; (JP).
SETO, Minoru; (JP)
Agent: SIKS & CO.; 8th Floor, Kyobashi-Nisshoku Bldg., 8-7, Kyobashi 1-chome, Chuo-ku, Tokyo 104-0031 (JP)
Priority Data:
2002-212053 22.07.2002 JP
2002-327751 12.11.2002 JP
Title (EN) 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE
(FR) DERIVE D'ISOQUINOLINE 5-SUBSTITUEE
(JA) 5−置換イソキノリン誘導体
Abstract: front page image
(EN)A compound represented by the following formula (1): (1) wherein R1 represents hydrogen, halogeno, etc.; R2 represents hydrogen, halogeno, C1-6 alkyl, etc.; R3 represents, e.g., -O-X-C(A1)(A11)-C(A2)(A21)-N(A31)(A3) (X represents propylene, etc.; A11 and A21 each represents hydrogen or C1-6 alkyl; A31 represents C1-6 hydroxyalkyl or hydrogen; and A1, A2, and A3 each represents hydrogen, C1-6 alkyl, etc.) or a salt of the compound. The compound or salt has myosin regulatory light-chain phosphorylation inhibitory activity and is useful in treatments for diseases to which contraction of various cells relates.
(FR)Cette invention se rapporte à un composé représenté par la formule (I), où R1 représente hydrogène, halogéno, etc.; R2 représente hydrogène, halogéno, alkyle C1-6, etc.; R3 représente par exemple O-X-C(A1) (A11)-C(A2) (A21)-N(A31) (A3) (où X représente propylène, etc.; A11 et A21 représentent chacun hydrogène ou alkyle C1-6; A31 représente hyroxyalkyle C1-6 ou hydrogène; et A1, A2 et A3 représentent chacun hydrogène, alkyle C1-6, etc.) ou un sel de ce composé. Ce composé ou son sel possèdent une action inhibitrice de la phosphorylation à chaîne légère régulatrice de la myosine et il peut servir dans le traitement de maladies auxquelles est liée la contraction de diverses cellules.
(JA)not available
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)